Nanoshell-based substrates for surface enhanced spectroscopic detection of biomolecules

Carly S Levin, Janardan Kundu, Aoune Barhoumi, Naomi J. Halas

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Nanoshells are optically tunable core-shell nanostructures with demonstrated uses in surface enhanced spectroscopies. Based on their ability to support surface plasmons, which give rise to strongly enhanced electromagnetic fields at their surface, nanoshells provide simple, scalable, high-quality substrates. In this article, we outline the development and use of nanoshell-based substrates for direct, spectroscopic detection of biomolecules. Recent advances in the use of these nanostructures lead to improved spectroscopic quality, selectivity, and reproducibility.

Original languageEnglish (US)
Pages (from-to)1745-50
Number of pages6
Issue number9
StatePublished - Sep 2009


  • DNA
  • Lipid Bilayers
  • Nanoshells
  • Peptides
  • Proteins
  • Spectrum Analysis, Raman
  • Surface Plasmon Resonance
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review


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