Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-off

Christine P. Tan, Benjamin R. Cipriany, David M. Lin, Harold G. Craighead

    Research output: Contribution to journalArticlepeer-review

    59 Scopus citations

    Abstract

    We present "Print-and-Peel", a high-throughput method to generate multicomponent biomolecular arrays with sub-100 nm nanoscale feature width. An inkjet printer is first aligned to a parylene template containing nanoscale openings. After printing, the parylene is peeled off to reveal uniformly patterned nanoscale features, despite the imperfect morphologies of the original inkjet spots. We further patterned combinatorial nanoarrays by performing a second print-run superimposed over the first, thereby extending the multiplexing capability of the technique.

    Original languageEnglish (US)
    Pages (from-to)719-725
    Number of pages7
    JournalNano Letters
    Volume10
    Issue number2
    DOIs
    StatePublished - Feb 10 2010

    Keywords

    • Multiplex
    • Nanoarray
    • Parylene
    • Patterning
    • Protein

    ASJC Scopus subject areas

    • Condensed Matter Physics
    • Bioengineering
    • General Chemistry
    • General Materials Science
    • Mechanical Engineering

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