Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-off

Christine P. Tan, Benjamin R. Cipriany, David M. Lin, Harold G. Craighead

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

We present "Print-and-Peel", a high-throughput method to generate multicomponent biomolecular arrays with sub-100 nm nanoscale feature width. An inkjet printer is first aligned to a parylene template containing nanoscale openings. After printing, the parylene is peeled off to reveal uniformly patterned nanoscale features, despite the imperfect morphologies of the original inkjet spots. We further patterned combinatorial nanoarrays by performing a second print-run superimposed over the first, thereby extending the multiplexing capability of the technique.

Original languageEnglish (US)
Pages (from-to)719-725
Number of pages7
JournalNano Letters
Volume10
Issue number2
DOIs
StatePublished - Feb 10 2010

Keywords

  • Multiplex
  • Nanoarray
  • Parylene
  • Patterning
  • Protein

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

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