Nanoprobes: Quantitatively detecting the femtogram level of arsenite ions in live cells

Ru Liu; Zhong Chen; Yaling Wang; Yanyan Cui; Huarui Zhu; Ping Huang; Wei Li; Yuliang Zhao; Ye Tao; Xueyun Gao

doi:10.1021/nn200994r

Nanoprobes: Quantitatively detecting the femtogram level of arsenite ions in live cells

Ru Liu, Zhong Chen, Yaling Wang, Yanyan Cui, Huarui Zhu, Ping Huang, Wei Li, Yuliang Zhao, Ye Tao, Xueyun Gao

Houston Methodist

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

In this report, nanoprobes which could detect the femtogram level of arsenite ions in subcellular organelle of live cells are disclosed. The nanoprobes are composed of ssDNA and single-wall carbon nanotubes (SWCNTs), and the ssDNA is marked by a dye molecule. In a live cell, trace arsenite ions could interact with nanoprobes and significantly decrease the emission of the nanoprobes. With the help of a confocal microscope and cryo-electron microscopy, the lysosome target of the arsenite ion and nanoprobe is well described in high spatial resolution.

Original language	English (US)
Pages (from-to)	5560-5565
Number of pages	6
Journal	ACS Nano
Volume	5
Issue number	7
DOIs	https://doi.org/10.1021/nn200994r
State	Published - Jul 26 2011

Keywords

arsenite ion
femtogram
live cell
nanoprobe
ssDNA
SWCNTs

ASJC Scopus subject areas

General Engineering
General Materials Science
General Physics and Astronomy

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10.1021/nn200994r

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abstract = "In this report, nanoprobes which could detect the femtogram level of arsenite ions in subcellular organelle of live cells are disclosed. The nanoprobes are composed of ssDNA and single-wall carbon nanotubes (SWCNTs), and the ssDNA is marked by a dye molecule. In a live cell, trace arsenite ions could interact with nanoprobes and significantly decrease the emission of the nanoprobes. With the help of a confocal microscope and cryo-electron microscopy, the lysosome target of the arsenite ion and nanoprobe is well described in high spatial resolution.",

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T2 - Quantitatively detecting the femtogram level of arsenite ions in live cells

AU - Liu, Ru

AU - Chen, Zhong

AU - Wang, Yaling

AU - Cui, Yanyan

AU - Zhu, Huarui

AU - Huang, Ping

AU - Li, Wei

AU - Zhao, Yuliang

AU - Tao, Ye

AU - Gao, Xueyun

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Y1 - 2011/7/26

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AB - In this report, nanoprobes which could detect the femtogram level of arsenite ions in subcellular organelle of live cells are disclosed. The nanoprobes are composed of ssDNA and single-wall carbon nanotubes (SWCNTs), and the ssDNA is marked by a dye molecule. In a live cell, trace arsenite ions could interact with nanoprobes and significantly decrease the emission of the nanoprobes. With the help of a confocal microscope and cryo-electron microscopy, the lysosome target of the arsenite ion and nanoprobe is well described in high spatial resolution.

KW - arsenite ion

KW - femtogram

KW - live cell

KW - nanoprobe

KW - ssDNA

KW - SWCNTs

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Nanoprobes: Quantitatively detecting the femtogram level of arsenite ions in live cells

Abstract

Keywords

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