Nanoprobes: Quantitatively detecting the femtogram level of arsenite ions in live cells

Ru Liu, Zhong Chen, Yaling Wang, Yanyan Cui, Huarui Zhu, Ping Huang, Wei Li, Yuliang Zhao, Ye Tao, Xueyun Gao

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

In this report, nanoprobes which could detect the femtogram level of arsenite ions in subcellular organelle of live cells are disclosed. The nanoprobes are composed of ssDNA and single-wall carbon nanotubes (SWCNTs), and the ssDNA is marked by a dye molecule. In a live cell, trace arsenite ions could interact with nanoprobes and significantly decrease the emission of the nanoprobes. With the help of a confocal microscope and cryo-electron microscopy, the lysosome target of the arsenite ion and nanoprobe is well described in high spatial resolution.

Original languageEnglish (US)
Pages (from-to)5560-5565
Number of pages6
JournalACS Nano
Volume5
Issue number7
DOIs
StatePublished - Jul 26 2011

Keywords

  • arsenite ion
  • femtogram
  • live cell
  • nanoprobe
  • ssDNA
  • SWCNTs

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)
  • Physics and Astronomy(all)

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