Nanoporous anti-fouling silicon membranes for biosensor applications

Tejal A. Desai, Derek J. Hansford, Lara Leoni, Matthias Essenpreis, Mauro Ferrari

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

The ability to create biocompatible well-controlled membranes has been an area of great interest over the last few years, particularly for biosensor applications. The present study describes the fabrication and characterization of novel nanoporous micromachined membranes that exhibit selective permeability and low biofouling. Results indicate that such membranes can be fabricated with uniform pore sizes capable of the simultaneous exclusion of albumin and diffusion of glucose. Compared to polymeric membranes of similar pore size, micromachined silicon membranes allowed more than twice the amount of glucose diffusion after 240 min and complete albumin exclusion. Moreover, membranes exhibit no morphological change or degradability in the presence of biological proteins and fluids at 37°C. The results point to the potential of using such membranes for implantable biosensor applications. With monodisperse pores sizes as small as 10 nm, these membranes offer advantages in their reproducibility, stability, and ability to be integrated in silicon-based biosensing technology. (C) 2000 Elsevier Science S.A.

Original languageEnglish (US)
Pages (from-to)453-462
Number of pages10
JournalBiosensors and Bioelectronics
Volume15
Issue number9-10
DOIs
StatePublished - Nov 2000

Keywords

  • Anti-fouling
  • Biosensor membrane
  • Microfabrication
  • Nanotechnology
  • Silicon

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Electrochemistry

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