Nanopore Technology for Biomedical Applications

Tejal A. Desai, Derek J. Hansford, Lawrence Kulinsky, Amir H. Nashat, Guido Rasi, Jay Tu, Yuchun Wang, Miqin Zhang, Mauro Ferrari

Research output: Contribution to journalArticle

162 Scopus citations

Abstract

The ability to create well-defined and controlled interfaces has been an area of great interest over the last few years, particularly in the biomedical arena. This paper will describe the development of technology for the fabrication of nanopore membranes, and their operation in biological environments. With monodisperse pores sizes as small as 10 nanometers, these membranes offer advantages in their reproducibility, and their ability to be integrated with controlled biochemical surface modification protocols. A comprehensive review of results in the areas of nanopore and biocapsule microfabrication technologies, biocompatibility of nanomembrane materials, biologically appropriate post-processing protocols (bonding, sterilization), surface modification protocols, and appropriate mass transport models will be presented. The results point to the potential of using such technologies for therapeutic applications including immunoisolation biocapsules, drug delivery devices, and targeted biorecognition platforms.

Original languageEnglish (US)
Pages (from-to)11-40
Number of pages30
JournalBiomedical Microdevices
Volume2
Issue number1
DOIs
StatePublished - 1999

Keywords

  • BioMEMS
  • Membranes
  • Microfabrication
  • Nanotechnology
  • Silicon

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Genetics
  • Neuroscience(all)

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