Nanoplatforms for mRNA Therapeutics

Chaoyang Meng; Zhe Chen; Gang Li; Thomas Welte; Haifa Shen

doi:10.1002/adtp.202000099

Nanoplatforms for mRNA Therapeutics

Chaoyang Meng, Zhe Chen, Gang Li, Thomas Welte, Haifa Shen

Research output: Contribution to journal › Review article › peer-review

36 Scopus citations

Abstract

mRNA-based therapeutics are a unique class of drugs for treatment of human diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents them from direct cell entry, they need to be packaged into specially designed delivery platforms to exert their activities. Multiple nanotechnology-based delivery platforms have been developed for mRNA delivery, such as polymer-based polyplex, lipid-based lipoplex, and lipid-coated polymer-based lipopolyplex. In this review, an overview of the nanoplatforms for mRNA delivery is provided. A number of applications in biotechnology including cell reprogramming and gene editing are also described. In addition, their clinical translational potential for protein replacement therapy and for infectious disease and cancer treatment is introduced.

Original language	English (US)
Article number	2000099
Journal	advanced therapeutics
Volume	4
Issue number	1
DOIs	https://doi.org/10.1002/adtp.202000099
State	Published - Jan 2021

Keywords

lipoplexes
lipopolyplexes
mRNA delivery
nanoplatforms
polyplexes

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology
Pharmaceutical Science
Genetics(clinical)
Biochemistry, medical
Pharmacology (medical)

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10.1002/adtp.202000099

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title = "Nanoplatforms for mRNA Therapeutics",

abstract = "mRNA-based therapeutics are a unique class of drugs for treatment of human diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents them from direct cell entry, they need to be packaged into specially designed delivery platforms to exert their activities. Multiple nanotechnology-based delivery platforms have been developed for mRNA delivery, such as polymer-based polyplex, lipid-based lipoplex, and lipid-coated polymer-based lipopolyplex. In this review, an overview of the nanoplatforms for mRNA delivery is provided. A number of applications in biotechnology including cell reprogramming and gene editing are also described. In addition, their clinical translational potential for protein replacement therapy and for infectious disease and cancer treatment is introduced.",

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author = "Chaoyang Meng and Zhe Chen and Gang Li and Thomas Welte and Haifa Shen",

note = "Funding Information: The authors acknowledge funding support from National Institutes of Health grants U54CA210181, R01CA193880, and R01CA222959. Publisher Copyright: {\textcopyright} 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Chen, Zhe

AU - Li, Gang

AU - Welte, Thomas

AU - Shen, Haifa

N1 - Funding Information: The authors acknowledge funding support from National Institutes of Health grants U54CA210181, R01CA193880, and R01CA222959. Publisher Copyright: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2021/1

Y1 - 2021/1

N2 - mRNA-based therapeutics are a unique class of drugs for treatment of human diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents them from direct cell entry, they need to be packaged into specially designed delivery platforms to exert their activities. Multiple nanotechnology-based delivery platforms have been developed for mRNA delivery, such as polymer-based polyplex, lipid-based lipoplex, and lipid-coated polymer-based lipopolyplex. In this review, an overview of the nanoplatforms for mRNA delivery is provided. A number of applications in biotechnology including cell reprogramming and gene editing are also described. In addition, their clinical translational potential for protein replacement therapy and for infectious disease and cancer treatment is introduced.

AB - mRNA-based therapeutics are a unique class of drugs for treatment of human diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents them from direct cell entry, they need to be packaged into specially designed delivery platforms to exert their activities. Multiple nanotechnology-based delivery platforms have been developed for mRNA delivery, such as polymer-based polyplex, lipid-based lipoplex, and lipid-coated polymer-based lipopolyplex. In this review, an overview of the nanoplatforms for mRNA delivery is provided. A number of applications in biotechnology including cell reprogramming and gene editing are also described. In addition, their clinical translational potential for protein replacement therapy and for infectious disease and cancer treatment is introduced.

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Nanoplatforms for mRNA Therapeutics

Abstract

Keywords

ASJC Scopus subject areas

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