Nanoplatforms for mRNA Therapeutics

Chaoyang Meng, Zhe Chen, Gang Li, Thomas Welte, Haifa Shen

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

mRNA-based therapeutics are a unique class of drugs for treatment of human diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their surface charge prevents them from direct cell entry, they need to be packaged into specially designed delivery platforms to exert their activities. Multiple nanotechnology-based delivery platforms have been developed for mRNA delivery, such as polymer-based polyplex, lipid-based lipoplex, and lipid-coated polymer-based lipopolyplex. In this review, an overview of the nanoplatforms for mRNA delivery is provided. A number of applications in biotechnology including cell reprogramming and gene editing are also described. In addition, their clinical translational potential for protein replacement therapy and for infectious disease and cancer treatment is introduced.

Original languageEnglish (US)
Article number2000099
Journaladvanced therapeutics
Volume4
Issue number1
DOIs
StatePublished - Jan 2021

Keywords

  • lipoplexes
  • lipopolyplexes
  • mRNA delivery
  • nanoplatforms
  • polyplexes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Pharmaceutical Science
  • Genetics(clinical)
  • Biochemistry, medical
  • Pharmacology (medical)

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