Nanoplasmonic platform for multiple biosensing applications

Nikhil Bhalla; Riccardo Funari; Amy Q. Shen

Nanoplasmonic platform for multiple biosensing applications

Nikhil Bhalla, Riccardo Funari, Amy Q. Shen

Houston Methodist

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We develop a nanoplasmonic platform with remarkable biocompatibility, for long-term survival of prokaryotic and eukaryotic cells, thereby enabling nanoplasmonic based cell bioassays. Our nanoplasmonic platform consists of large areas (~18.75 cm²) of densely packed (>10⁶/cm²) mushroom-like nanostructures on silicon-oxide (SiO2) substrates, where each nanomushroom (NM) consists of a SiO2 stem and a gold cap. This NM platform is used for monitoring mitosis of fibroblasts for 7 days, E. coli biofilm formation in real-time. In addition, the same nanoplasmonic platform is used to conduct routine protein/DNA based immunoassays with a limit of detection of ∼66 zM.

Original language	English (US)
Title of host publication	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Publisher	Chemical and Biological Microsystems Society
Pages	157-160
Number of pages	4
Volume	1
ISBN (Electronic)	9781510897571
State	Published - Jan 1 2018
Event	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China Duration: Nov 11 2018 → Nov 15 2018

Other

Other	22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Country/Territory	Taiwan, Province of China
City	Kaohsiung
Period	11/11/18 → 11/15/18

Keywords

Bacteria-biofilm
Cell-bioassays
Immunoassays
LSPR

ASJC Scopus subject areas

General Chemistry
Bioengineering
Chemical Engineering (miscellaneous)
Control and Systems Engineering

Cite this

Nanoplasmonic platform for multiple biosensing applications. / Bhalla, Nikhil; Funari, Riccardo; Shen, Amy Q.
22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. Vol. 1 Chemical and Biological Microsystems Society, 2018. p. 157-160.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Bhalla, N, Funari, R & Shen, AQ 2018, Nanoplasmonic platform for multiple biosensing applications. in 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018. vol. 1, Chemical and Biological Microsystems Society, pp. 157-160, 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018, Kaohsiung, Taiwan, Province of China, 11/11/18.

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abstract = "We develop a nanoplasmonic platform with remarkable biocompatibility, for long-term survival of prokaryotic and eukaryotic cells, thereby enabling nanoplasmonic based cell bioassays. Our nanoplasmonic platform consists of large areas (\textasciitilde{}18.75 cm2) of densely packed (>106/cm2) mushroom-like nanostructures on silicon-oxide (SiO2) substrates, where each nanomushroom (NM) consists of a SiO2 stem and a gold cap. This NM platform is used for monitoring mitosis of fibroblasts for 7 days, E. coli biofilm formation in real-time. In addition, the same nanoplasmonic platform is used to conduct routine protein/DNA based immunoassays with a limit of detection of ∼66 zM.",

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N2 - We develop a nanoplasmonic platform with remarkable biocompatibility, for long-term survival of prokaryotic and eukaryotic cells, thereby enabling nanoplasmonic based cell bioassays. Our nanoplasmonic platform consists of large areas (~18.75 cm2) of densely packed (>106/cm2) mushroom-like nanostructures on silicon-oxide (SiO2) substrates, where each nanomushroom (NM) consists of a SiO2 stem and a gold cap. This NM platform is used for monitoring mitosis of fibroblasts for 7 days, E. coli biofilm formation in real-time. In addition, the same nanoplasmonic platform is used to conduct routine protein/DNA based immunoassays with a limit of detection of ∼66 zM.

AB - We develop a nanoplasmonic platform with remarkable biocompatibility, for long-term survival of prokaryotic and eukaryotic cells, thereby enabling nanoplasmonic based cell bioassays. Our nanoplasmonic platform consists of large areas (~18.75 cm2) of densely packed (>106/cm2) mushroom-like nanostructures on silicon-oxide (SiO2) substrates, where each nanomushroom (NM) consists of a SiO2 stem and a gold cap. This NM platform is used for monitoring mitosis of fibroblasts for 7 days, E. coli biofilm formation in real-time. In addition, the same nanoplasmonic platform is used to conduct routine protein/DNA based immunoassays with a limit of detection of ∼66 zM.

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KW - Cell-bioassays

KW - Immunoassays

KW - LSPR

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T2 - 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018

Y2 - 11 November 2018 through 15 November 2018

ER -

Nanoplasmonic platform for multiple biosensing applications

Abstract

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Keywords

ASJC Scopus subject areas

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