Nanoplasmonic platform for multiple biosensing applications

Nikhil Bhalla, Riccardo Funari, Amy Q. Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We develop a nanoplasmonic platform with remarkable biocompatibility, for long-term survival of prokaryotic and eukaryotic cells, thereby enabling nanoplasmonic based cell bioassays. Our nanoplasmonic platform consists of large areas (~18.75 cm2) of densely packed (>106/cm2) mushroom-like nanostructures on silicon-oxide (SiO2) substrates, where each nanomushroom (NM) consists of a SiO2 stem and a gold cap. This NM platform is used for monitoring mitosis of fibroblasts for 7 days, E. coli biofilm formation in real-time. In addition, the same nanoplasmonic platform is used to conduct routine protein/DNA based immunoassays with a limit of detection of ∼66 zM.

Original languageEnglish (US)
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages157-160
Number of pages4
Volume1
ISBN (Electronic)9781510897571
StatePublished - Jan 1 2018
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: Nov 11 2018Nov 15 2018

Other

Other22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period11/11/1811/15/18

Keywords

  • Bacteria-biofilm
  • Cell-bioassays
  • Immunoassays
  • LSPR

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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