TY - JOUR
T1 - Nanoparticles in cellular drug delivery
AU - Faraji, Amir H.
AU - Wipf, Peter
N1 - Funding Information:
We are grateful for support from the National Institutes of Health (GM067082), the National Institute of Allergy and Infectious Diseases (AI33507), and the CMCR program (U19-AI068021). We would also like to acknowledge valuable suggestions of Dr. A. S. Dömling (University of Pittsburgh, Department of Pharmaceutical Sciences) in the preparation of this manuscript.
PY - 2009/4/15
Y1 - 2009/4/15
N2 - This review highlights the properties of nanoparticles used in targeted drug delivery, including delivery to cells as well as organelle targets, some of the known pharmacokinetic properties of nanoparticles, and their typical modifications to allow for therapeutic delivery. Nanoparticles exploit biological pathways to achieve payload delivery to cellular and intracellular targets, including transport past the blood-brain barrier. As illustrative examples of their utility, the evaluation of targeted nanoparticles in the treatment of cancers and diseases of the central nervous system, such as glioblastoma multiforme, neurovascular disorders, and neurodegenerative diseases, is discussed.
AB - This review highlights the properties of nanoparticles used in targeted drug delivery, including delivery to cells as well as organelle targets, some of the known pharmacokinetic properties of nanoparticles, and their typical modifications to allow for therapeutic delivery. Nanoparticles exploit biological pathways to achieve payload delivery to cellular and intracellular targets, including transport past the blood-brain barrier. As illustrative examples of their utility, the evaluation of targeted nanoparticles in the treatment of cancers and diseases of the central nervous system, such as glioblastoma multiforme, neurovascular disorders, and neurodegenerative diseases, is discussed.
KW - Drug delivery
KW - Nanomaterials
KW - Nanoparticles
KW - Targeted therapeutics
UR - http://www.scopus.com/inward/record.url?scp=64049086772&partnerID=8YFLogxK
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U2 - 10.1016/j.bmc.2009.02.043
DO - 10.1016/j.bmc.2009.02.043
M3 - Review article
C2 - 19299149
AN - SCOPUS:64049086772
SN - 0968-0896
VL - 17
SP - 2950
EP - 2962
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 8
ER -