Nanoparticles in cellular drug delivery

Amir H. Faraji, Peter Wipf

Research output: Contribution to journalReview articlepeer-review

733 Scopus citations


This review highlights the properties of nanoparticles used in targeted drug delivery, including delivery to cells as well as organelle targets, some of the known pharmacokinetic properties of nanoparticles, and their typical modifications to allow for therapeutic delivery. Nanoparticles exploit biological pathways to achieve payload delivery to cellular and intracellular targets, including transport past the blood-brain barrier. As illustrative examples of their utility, the evaluation of targeted nanoparticles in the treatment of cancers and diseases of the central nervous system, such as glioblastoma multiforme, neurovascular disorders, and neurodegenerative diseases, is discussed.

Original languageEnglish (US)
Pages (from-to)2950-2962
Number of pages13
JournalBioorganic and Medicinal Chemistry
Issue number8
StatePublished - Apr 15 2009


  • Drug delivery
  • Nanomaterials
  • Nanoparticles
  • Targeted therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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