Nanoparticle transport pathways into tumors

S. M. Moghimi; D. Simberg

doi:10.1007/s11051-018-4273-8

Nanoparticle transport pathways into tumors

S. M. Moghimi, D. Simberg

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.

Original language	English (US)
Article number	169
Journal	Journal of Nanoparticle Research
Volume	20
Issue number	6
DOIs	https://doi.org/10.1007/s11051-018-4273-8
State	Published - Jun 1 2018

Keywords

Interendothelial transport
Nanomedicine
Nanoparticle
Nanoparticle accumulation in tumors
Solid tumors
Transendothelial transport

ASJC Scopus subject areas

Bioengineering
Atomic and Molecular Physics, and Optics
General Chemistry
Modeling and Simulation
General Materials Science
Condensed Matter Physics

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10.1007/s11051-018-4273-8

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title = "Nanoparticle transport pathways into tumors",

abstract = "Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.",

keywords = "Interendothelial transport, Nanomedicine, Nanoparticle, Nanoparticle accumulation in tumors, Solid tumors, Transendothelial transport",

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AU - Simberg, D.

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AB - Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.

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KW - Nanomedicine

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KW - Nanoparticle accumulation in tumors

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KW - Transendothelial transport

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Nanoparticle transport pathways into tumors

Abstract

Keywords

ASJC Scopus subject areas

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