Nanoparticle transport pathways into tumors

S. M. Moghimi, D. Simberg

    Research output: Contribution to journalArticlepeer-review

    53 Scopus citations

    Abstract

    Two transport pathways (interendothelial and transendothelial routes) have long been proposed for entry of nanoparticles from the blood circulation into solid tumors. We examine and discuss available evidence supporting interendothelial and transendothelial transport processes and suggest new avenues for re-evaluating these pathways. Understanding of integrative mechanisms controlling nanoparticle extravasation into tumors is important for improving engineering and performance of anti-cancer nanopharmaceuticals.

    Original languageEnglish (US)
    Article number169
    JournalJournal of Nanoparticle Research
    Volume20
    Issue number6
    DOIs
    StatePublished - Jun 1 2018

    Keywords

    • Interendothelial transport
    • Nanomedicine
    • Nanoparticle
    • Nanoparticle accumulation in tumors
    • Solid tumors
    • Transendothelial transport

    ASJC Scopus subject areas

    • Bioengineering
    • Atomic and Molecular Physics, and Optics
    • General Chemistry
    • Modeling and Simulation
    • General Materials Science
    • Condensed Matter Physics

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