Nanoparticle-mediated gene delivery to tumour neovasculature

Andrew R. Reynolds; S. Moein Moghimi; Kairbaan Hodivala-Dilke

doi:10.1016/S1471-4914(02)00004-7

Nanoparticle-mediated gene delivery to tumour neovasculature

Andrew R. Reynolds, S. Moein Moghimi, Kairbaan Hodivala-Dilke

Research output: Contribution to journal › Short survey › peer-review

60 Scopus citations

Abstract

The α_vβ₃ integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of α_vβ₃-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.

Original language	English (US)
Pages (from-to)	2-4
Number of pages	3
Journal	Trends in Molecular Medicine
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/S1471-4914(02)00004-7
State	Published - Jan 1 2003

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/S1471-4914(02)00004-7

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title = "Nanoparticle-mediated gene delivery to tumour neovasculature",

abstract = "The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.",

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AB - The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.

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Nanoparticle-mediated gene delivery to tumour neovasculature

Abstract

ASJC Scopus subject areas

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