Nanoparticle-mediated gene delivery to tumour neovasculature

Andrew R. Reynolds, S. Moein Moghimi, Kairbaan Hodivala-Dilke

Research output: Contribution to journalShort survey

55 Scopus citations

Abstract

The αvβ3 integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of αvβ3-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.

Original languageEnglish (US)
Pages (from-to)2-4
Number of pages3
JournalTrends in Molecular Medicine
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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