Nanomedicine-Based Immunotherapy for the Treatment of Cancer Metastasis

Pengcheng Zhang, Yihui Zhai, Ying Cai, Yuliang Zhao, Yaping Li

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

Metastasis is the leading cause of cancer-associated death, with poor prognosis even after extensive treatment. The dormancy of metastatic cancer cells during dissemination or after colony formation is one major reason for treatment failure, as most drugs target cells of active proliferation. Immunotherapy has shown great potential in cancer therapy because the activity of effector cells is less affected by the metabolic status of cancer cells. In addition, metastatic cells out of immunosuppressive tumor microenvironment (TME) are more susceptible to immune clearance, although these cells can achieve immune surveillance evasion via strategies such as platelet and macrophage recruitment. Since nanomaterials themselves or their carried drugs have the capability to modulate the immune system, a great amount of focus has been placed on nanomedicine strategies that leverage immune cells participating the metastatic cascade. These nanomedicines successfully inhibit the tumor metastasis and prolong the survival of model animals. Immune cells that are involved in the metastasis cascade are first summarized and then recent and inspiring strategies and nanomaterials in this growing field are highlighted.

Original languageEnglish (US)
Article number1904156
JournalAdvanced Materials
Volume31
Issue number49
DOIs
StatePublished - Dec 1 2019

Keywords

  • cancer
  • immunotherapy
  • metastasis
  • nanomaterials
  • nanomedicine

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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