Nanomaterial-modulated autophagy: Underlying mechanisms and functional consequences

Wei Zheng, Min Wei, Song Li, Weidong Le

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Autophagy is an essential lysosome-dependent process that controls the quality of the cytoplasm and maintains cellular homeostasis, and dysfunction of this protein degradation system is correlated with various disorders. A growing body of evidence suggests that nanomaterials (NMs) have autophagy-modulating effects, thus predicting a valuable and promising application potential of NMs in the diagnosis and treatment of autophagy-related diseases. NMs exhibit unique physical, chemical and biofunctional properties, which may endow NMs with capabilities to modulate autophagy via various mechanisms. The present review highlights the impacts of various NMs on autophagy and their functional consequences. The possible underlying mechanisms for NM-modulated autophagy are also discussed.

Original languageEnglish (US)
Pages (from-to)1417-1430
Number of pages14
JournalNanomedicine
Volume11
Issue number11
DOIs
StatePublished - Jun 2016

Keywords

  • autophagy
  • autophagy-modulating effect
  • nanomaterials

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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