Nanoengineered device for drug delivery application

Piyush M. Sinha; George Valco; Sadhana Sharma; Xuewu Liu; Mauro Ferrari

doi:10.1088/0957-4484/15/10/015

Nanoengineered device for drug delivery application

Piyush M. Sinha, George Valco, Sadhana Sharma, Xuewu Liu, Mauro Ferrari

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

A high precision nanoengineered device was developed to yield long term zero-order release of drugs for therapeutic applications. The device contains nanochannels that were fabricated in between two directly bonded silicon wafers and therefore poses high mechanical strength. The fabrication is based upon selectively growing oxide and then removing it, and thus defining nanochannels by consuming a specified layer of silicon during oxide growth. Diffusion through the nanochannels is the rate limiting step for the release of drugs. A measurement of glucose released through such nanochannels validates the zero-order release profile. Device design, fabrication details and the glucose release profile through 60 nm channels are presented.

Original language	English (US)
Journal	Nanotechnology
Volume	15
Issue number	10
DOIs	https://doi.org/10.1088/0957-4484/15/10/015
State	Published - Oct 1 2004

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Mechanics of Materials
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1088/0957-4484/15/10/015

Cite this

@article{c65a55b4bd9646ae8b58d62483927420,

title = "Nanoengineered device for drug delivery application",

abstract = "A high precision nanoengineered device was developed to yield long term zero-order release of drugs for therapeutic applications. The device contains nanochannels that were fabricated in between two directly bonded silicon wafers and therefore poses high mechanical strength. The fabrication is based upon selectively growing oxide and then removing it, and thus defining nanochannels by consuming a specified layer of silicon during oxide growth. Diffusion through the nanochannels is the rate limiting step for the release of drugs. A measurement of glucose released through such nanochannels validates the zero-order release profile. Device design, fabrication details and the glucose release profile through 60 nm channels are presented.",

author = "Sinha, {Piyush M.} and George Valco and Sadhana Sharma and Xuewu Liu and Mauro Ferrari",

year = "2004",

month = oct,

day = "1",

doi = "10.1088/0957-4484/15/10/015",

language = "English (US)",

volume = "15",

journal = "Nanotechnology",

issn = "0957-4484",

publisher = "IOP Publishing Ltd.",

number = "10",

}

TY - JOUR

T1 - Nanoengineered device for drug delivery application

AU - Sinha, Piyush M.

AU - Valco, George

AU - Sharma, Sadhana

AU - Liu, Xuewu

AU - Ferrari, Mauro

PY - 2004/10/1

Y1 - 2004/10/1

N2 - A high precision nanoengineered device was developed to yield long term zero-order release of drugs for therapeutic applications. The device contains nanochannels that were fabricated in between two directly bonded silicon wafers and therefore poses high mechanical strength. The fabrication is based upon selectively growing oxide and then removing it, and thus defining nanochannels by consuming a specified layer of silicon during oxide growth. Diffusion through the nanochannels is the rate limiting step for the release of drugs. A measurement of glucose released through such nanochannels validates the zero-order release profile. Device design, fabrication details and the glucose release profile through 60 nm channels are presented.

AB - A high precision nanoengineered device was developed to yield long term zero-order release of drugs for therapeutic applications. The device contains nanochannels that were fabricated in between two directly bonded silicon wafers and therefore poses high mechanical strength. The fabrication is based upon selectively growing oxide and then removing it, and thus defining nanochannels by consuming a specified layer of silicon during oxide growth. Diffusion through the nanochannels is the rate limiting step for the release of drugs. A measurement of glucose released through such nanochannels validates the zero-order release profile. Device design, fabrication details and the glucose release profile through 60 nm channels are presented.

UR - http://www.scopus.com/inward/record.url?scp=7044265023&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7044265023&partnerID=8YFLogxK

U2 - 10.1088/0957-4484/15/10/015

DO - 10.1088/0957-4484/15/10/015

M3 - Article

AN - SCOPUS:7044265023

VL - 15

JO - Nanotechnology

JF - Nanotechnology

SN - 0957-4484

IS - 10

ER -

Nanoengineered device for drug delivery application

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this