Nanodisk codes

Lidong Qin; Matthew J. Banholzer; Jill E. Millstone; Chad A. Mirkin

doi:10.1021/nl072606s

Nanodisk codes

Lidong Qin, Matthew J. Banholzer, Jill E. Millstone, Chad A. Mirkin

Academic Institute

Research output: Contribution to journal › Article › peer-review

138 Scopus citations

Abstract

We report a new encoding system based upon dispersible arrays of nanodisks prepared by on-wire lithography and functionalized with Raman active chromophores. These nanodisk arrays are encoded both physically (in a "barcode" pattern) and spectroscopically (Raman) along the array. These structures can be used in covert encoding strategies because of their small size or as biological labels with readout by scanning confocal Raman spectroscopy. As proof-of-concept, we demonstrate their utility in DNA detection in a multiplexed format at target concentrations as low as 100 fM.

Original language	English (US)
Pages (from-to)	3849-3853
Number of pages	5
Journal	Nano Letters
Volume	7
Issue number	12
DOIs	https://doi.org/10.1021/nl072606s
State	Published - Dec 2007

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl072606s

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AU - Qin, Lidong

AU - Banholzer, Matthew J.

AU - Millstone, Jill E.

AU - Mirkin, Chad A.

PY - 2007/12

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N2 - We report a new encoding system based upon dispersible arrays of nanodisks prepared by on-wire lithography and functionalized with Raman active chromophores. These nanodisk arrays are encoded both physically (in a "barcode" pattern) and spectroscopically (Raman) along the array. These structures can be used in covert encoding strategies because of their small size or as biological labels with readout by scanning confocal Raman spectroscopy. As proof-of-concept, we demonstrate their utility in DNA detection in a multiplexed format at target concentrations as low as 100 fM.

AB - We report a new encoding system based upon dispersible arrays of nanodisks prepared by on-wire lithography and functionalized with Raman active chromophores. These nanodisk arrays are encoded both physically (in a "barcode" pattern) and spectroscopically (Raman) along the array. These structures can be used in covert encoding strategies because of their small size or as biological labels with readout by scanning confocal Raman spectroscopy. As proof-of-concept, we demonstrate their utility in DNA detection in a multiplexed format at target concentrations as low as 100 fM.

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JO - Nano Letters

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Nanodisk codes

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ASJC Scopus subject areas

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