Nanochannel technology for constant delivery of chemotherapeutics: Beyond metronomic administration

Alessandro Grattoni, Haifa Shen, Daniel Fine, Arturas Ziemys, Jaskaran S. Gill, Lee Hudson, Sharath Hosali, Randy Goodall, Xuewu Liu, Mauro Ferrari

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Purpose: The purpose of this study is to demonstrate the long-term, controlled, zero-order release of low- and high-molecular weight chemotherapeutics through nanochannel membranes by exploiting the molecule-to-surface interactions presented by nanoconfinement. Methods: Silicon membranes were produced with nanochannels of 5, 13 and 20 nm using standardized industrial microfabrication techniques. The study of the diffusion kinetics of interferonα-2b and leuprolide was performed by employing UV diffusion chambers. The released amount in the sink reservoir was monitored by UV absorbance. Results: Continuous zero-order release was demonstrated for interferonα-2b and leuprolide at release rates of 20 and 100 μg/day, respectively. The release rates exhibited by these membranes were verified to be in ranges suitable for human therapeutic applications. Conclusions: Our membranes potentially represent a viable nanotechnological approach for the controlled administration of chemotherapeutics intended to improve the therapeutic efficacy of treatment and reduce many of the side effects associated with conventional drug administration.

Original languageEnglish (US)
Pages (from-to)292-300
Number of pages9
JournalPharmaceutical Research
Volume28
Issue number2
DOIs
StatePublished - Feb 2011

Keywords

  • chemotherapy
  • controlled release
  • drug delivery
  • implants
  • nanochannel

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology (medical)
  • Biotechnology
  • Pharmacology

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