Nanochannel implants for minimally-invasive insertion and intratumoral delivery

R. Lyle Hood, Giacomo Bruno, Priya Jain, Jeff Anderson, Tatiana Wolfe, Caio Quini, Jeffery Schmulen, Xian C. Li, E. Brian Butler, Sunil Krishnan, Alessandro Grattoni

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Novel approaches to achieve local, intratumoral drug delivery have the dual benefit of reducing systemic toxicity while enhancing efficacy for malignant cells. We have developed a new implantable system combining a next-generation BioNEMS nanofluidic membrane with parallel nanochannels that offers controlled release of biomolecules. Based on concentration-driven diffusive transport, nanochannel membranes provide a "drug agnostic" delivery mechanism. Integrating this nanotechnology within a small implantable capsule permits multipurpose functionality and compatibility with different therapeutic approaches as well as diagnostic imaging capability. A minimally-invasive, percutaneous trocar delivery mechanism enables serial implantation throughout a target tissue volume. In this manuscript, we demonstrate that this platform is capable of sustained delivery for chemotherapy, radiosensitization, immunomodulation, and imaging contrast, among others. This platform's utility was established through release of doxorubicin, OX86, FGK45, and Magnevist. Further proof-of-concept experiments demonstrated successful in vivo implantation and intratumoral release of antibodies and contrast agents, as well as the platform's MR-compatibility and capability as a radiopaque fiducial. These results provide strong evidence for a flexible, multifunctional nanofluidic implant capable of broadening local delivery utility in the clinic.

Original languageEnglish (US)
Pages (from-to)1907-1915
Number of pages9
JournalJournal of Biomedical Nanotechnology
Volume12
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • BioNEMS Device
  • Controlled Delivery
  • Fiducial Marker
  • Imaging Contrast
  • Intratumoral Release
  • Localized Drug Delivery
  • Nanoconstrained Diffusion
  • Nanofluidics
  • Nanotechnology.
  • Radiosensitization

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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