NALOXONE REVERSAL OF ISCHAEMIC NEUROLOGICAL DEFICITS IN MAN

David S. Baskin; Yoshio Hosobuchi

doi:10.1016/S0140-6736(81)90524-9

NALOXONE REVERSAL OF ISCHAEMIC NEUROLOGICAL DEFICITS IN MAN

David S. Baskin, Yoshio Hosobuchi

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172 Scopus citations

Abstract

Two patients with cerebral ischaemia and one patient with cerebral infarction received intravenous infusions of the opiate antagonist naloxone or saline in double-blind manner. Naloxone completely reversed neurological deficits in both patients with cerebral ischaemia, but did not in the patient with cerebral infarction. Naloxone administration produced no changes in blood pressure, pulse rate, respiratory rate, temperature, or arterial blood gases. Intravenous administration of morphine sulphate profoundly exacerbated hemiparesis in one patient without alteration of vital signs; hemiparesis was completely reversed by naloxone.

Original language	English (US)
Pages (from-to)	272-275
Number of pages	4
Journal	The Lancet
Volume	318
Issue number	8241
DOIs	https://doi.org/10.1016/S0140-6736(81)90524-9
State	Published - Aug 8 1981

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Medicine(all)

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title = "NALOXONE REVERSAL OF ISCHAEMIC NEUROLOGICAL DEFICITS IN MAN",

abstract = "Two patients with cerebral ischaemia and one patient with cerebral infarction received intravenous infusions of the opiate antagonist naloxone or saline in double-blind manner. Naloxone completely reversed neurological deficits in both patients with cerebral ischaemia, but did not in the patient with cerebral infarction. Naloxone administration produced no changes in blood pressure, pulse rate, respiratory rate, temperature, or arterial blood gases. Intravenous administration of morphine sulphate profoundly exacerbated hemiparesis in one patient without alteration of vital signs; hemiparesis was completely reversed by naloxone.",

author = "Baskin, {David S.} and Yoshio Hosobuchi",

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N2 - Two patients with cerebral ischaemia and one patient with cerebral infarction received intravenous infusions of the opiate antagonist naloxone or saline in double-blind manner. Naloxone completely reversed neurological deficits in both patients with cerebral ischaemia, but did not in the patient with cerebral infarction. Naloxone administration produced no changes in blood pressure, pulse rate, respiratory rate, temperature, or arterial blood gases. Intravenous administration of morphine sulphate profoundly exacerbated hemiparesis in one patient without alteration of vital signs; hemiparesis was completely reversed by naloxone.

AB - Two patients with cerebral ischaemia and one patient with cerebral infarction received intravenous infusions of the opiate antagonist naloxone or saline in double-blind manner. Naloxone completely reversed neurological deficits in both patients with cerebral ischaemia, but did not in the patient with cerebral infarction. Naloxone administration produced no changes in blood pressure, pulse rate, respiratory rate, temperature, or arterial blood gases. Intravenous administration of morphine sulphate profoundly exacerbated hemiparesis in one patient without alteration of vital signs; hemiparesis was completely reversed by naloxone.

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ER -

NALOXONE REVERSAL OF ISCHAEMIC NEUROLOGICAL DEFICITS IN MAN

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