Two patients with cerebral ischaemia and one patient with cerebral infarction received intravenous infusions of the opiate antagonist naloxone or saline in double-blind manner. Naloxone completely reversed neurological deficits in both patients with cerebral ischaemia, but did not in the patient with cerebral infarction. Naloxone administration produced no changes in blood pressure, pulse rate, respiratory rate, temperature, or arterial blood gases. Intravenous administration of morphine sulphate profoundly exacerbated hemiparesis in one patient without alteration of vital signs; hemiparesis was completely reversed by naloxone.

Original languageEnglish (US)
Pages (from-to)272-275
Number of pages4
JournalThe Lancet
Issue number8241
StatePublished - Aug 8 1981

ASJC Scopus subject areas

  • Medicine(all)


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