Naissance of the archives of pathology and laboratory medicine: A critical analysis of the January 1926, Volume 1 Issue

As the clinical field of prostate cancer has changed dramatically during the last few decades, so too has the grading of prostate cancer. These changes will enable clinicians to better manage prostate cancer patients, which is the ultimate goal of any grading system. Initially, the new grading system for prostate cancer will be a "translation" from the much modified original Gleason system (ie, Gleason score 3 + 3 = 6 = Grade Group 1). However, ultimately pathologists and clinicians will learn the new system directly (ie, Grade Group 1 = discrete, well-formed glands) without the need to "think in Gleason".