Myxoid adrenocortical carcinoma

Annikka Weissferdt, Alexandria Phan, Saul Suster, Cesar A. Moran

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Adrenocortical carcinomas (ACCs) with myxoid features are rare neoplasms. We identified 7 cases of myxoid ACC and studied the clinicopathologic and immunohistochemical features of these neoplasms. The patients were 5 men and 2 women with a mean age of 45 years. Histologically, the tumors contained alcian blue-positive myxoid areas ranging from 10% to 50% of the tissue examined. One case showed lipomatous metaplasia. Areas of conventional ACC were present in all cases. Immunohistochemically, the tumors were positive for steroid receptor cofactor 1, inhibin, melan A, calretinin, and synaptophysin but negative for high-molecular-weight cytokeratin, CAM5.2, and Pax8. Clinical follow-up information for 4 patients demonstrated that all patients had died of their disease 11 to 69 months after diagnosis. Myxoid ACCs are rare tumors that expand the differential diagnosis of myxoid neoplasms involving the retroperitoneum. Contrary to previous reports proposing that the biologic behavior is similar to conventional ACC, our series seems to indicate that myxoid morphology is associated with more aggressive behavior.

Original languageEnglish (US)
Pages (from-to)780-786
Number of pages7
JournalAmerican Journal of Clinical Pathology
Issue number6
StatePublished - Jun 2013


  • Adrenocortical carcinoma
  • Endocrine tumor
  • Immunohistochemistry
  • Myxoid change

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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