TY - JOUR
T1 - Myocardial Perfusion Imaging Using Positron Emission Tomography
AU - El-Tallawi, K. Carlos
AU - Aljizeeri, Ahmed
AU - Nabi, Faisal
AU - Al-Mallah, Mouaz
N1 - © 2020 Houston Methodist Hospital Houston, Texas.
PY - 2020/7/17
Y1 - 2020/7/17
N2 - Coronary artery disease (CAD), also known as ischemic heart disease, is a major cause of morbidity and mortality worldwide, and timely noninvasive diagnosis of clinical and subclinical CAD is imperative to mitigate its burden on individual patients and populations. Positron emission tomography (PET) is a versatile tool that can perform relative myocardial perfusion imaging (MPI) with high accuracy; furthermore, it provides valuable information about the coronary microvasculature using rest and stress myocardial blood flow (MBF) and coronary flow reserve (CFR) measurements. Several radiotracers are approved by the US Food and Drug Administration to help with MPI, MBF, and CFR evaluation. A large body of evidence indicates that evaluation of the coronary microcirculation using MBF and CFR provides strong diagnostic and prognostic data in a multitude of patient populations. This review describes the technical aspects of PET compared to other modalities and discusses its clinical uses for diagnosis and prognosis of coronary arterial epicardial and microcirculatory disease.
AB - Coronary artery disease (CAD), also known as ischemic heart disease, is a major cause of morbidity and mortality worldwide, and timely noninvasive diagnosis of clinical and subclinical CAD is imperative to mitigate its burden on individual patients and populations. Positron emission tomography (PET) is a versatile tool that can perform relative myocardial perfusion imaging (MPI) with high accuracy; furthermore, it provides valuable information about the coronary microvasculature using rest and stress myocardial blood flow (MBF) and coronary flow reserve (CFR) measurements. Several radiotracers are approved by the US Food and Drug Administration to help with MPI, MBF, and CFR evaluation. A large body of evidence indicates that evaluation of the coronary microcirculation using MBF and CFR provides strong diagnostic and prognostic data in a multitude of patient populations. This review describes the technical aspects of PET compared to other modalities and discusses its clinical uses for diagnosis and prognosis of coronary arterial epicardial and microcirculatory disease.
KW - coronary flow reserve
KW - endothelial dysfunction
KW - myocardial blood flow
KW - positron emission tomography
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U2 - 10.14797/mdcj-16-2-114
DO - 10.14797/mdcj-16-2-114
M3 - Review article
C2 - 32670471
AN - SCOPUS:85088157188
VL - 16
SP - 114
EP - 121
JO - Methodist DeBakey cardiovascular journal
JF - Methodist DeBakey cardiovascular journal
SN - 1947-6094
IS - 2
ER -