Myocardial Perfusion Imaging Using Positron Emission Tomography

K. Carlos El-Tallawi, Ahmed Aljizeeri, Faisal Nabi, Mouaz Al-Mallah

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Coronary artery disease (CAD), also known as ischemic heart disease, is a major cause of morbidity and mortality worldwide, and timely noninvasive diagnosis of clinical and subclinical CAD is imperative to mitigate its burden on individual patients and populations. Positron emission tomography (PET) is a versatile tool that can perform relative myocardial perfusion imaging (MPI) with high accuracy; furthermore, it provides valuable information about the coronary microvasculature using rest and stress myocardial blood flow (MBF) and coronary flow reserve (CFR) measurements. Several radiotracers are approved by the US Food and Drug Administration to help with MPI, MBF, and CFR evaluation. A large body of evidence indicates that evaluation of the coronary microcirculation using MBF and CFR provides strong diagnostic and prognostic data in a multitude of patient populations. This review describes the technical aspects of PET compared to other modalities and discusses its clinical uses for diagnosis and prognosis of coronary arterial epicardial and microcirculatory disease.

Original languageEnglish (US)
Pages (from-to)114-121
Number of pages8
JournalMethodist DeBakey cardiovascular journal
Issue number2
StatePublished - Jul 17 2020


  • coronary flow reserve
  • endothelial dysfunction
  • myocardial blood flow
  • positron emission tomography

ASJC Scopus subject areas

  • Medicine(all)


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