Myocardial Infarction as a Clinical End Point in Research: What Are We Really Talking About?

Andrew P. Defilippis; Khurram Nasir; Michael J. Blaha

doi:10.1161/CIRCRESAHA.119.315101

Myocardial Infarction as a Clinical End Point in Research: What Are We Really Talking About?

Andrew P. Defilippis, Khurram Nasir, Michael J. Blaha

Research output: Contribution to journal › Review article

3 Scopus citations

Abstract

Reflecting the greater understanding of the many diverse causes of myocardial injury, international consensus definition of myocardial injury now includes nonischemic causes of myocardial injury and several etiologically distinct subtypes of myocardial infarction (MI). It is time that all ongoing prospective cohorts and clinical trials systematically differentiate and report on all the etiologically distinct types of myocardial injury. Such reporting will undoubtedly advance the fundamental understanding of the epidemiology of myocardial injury events, including differing risk factor associations, allowing better prediction, prevention, and pharmacotherapies for all identified subtypes of myocardial injury events-including all subtypes of MI.

Original language	English (US)
Pages (from-to)	1701-1703
Number of pages	3
Journal	Circulation Research
Volume	124
Issue number	12
DOIs	https://doi.org/10.1161/CIRCRESAHA.119.315101
State	Published - Jun 7 2019

Keywords

acute coronary syndrome
ischemia
myocardial infarction
prospective studies
risk factors

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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10.1161/CIRCRESAHA.119.315101

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title = "Myocardial Infarction as a Clinical End Point in Research: What Are We Really Talking About?",

abstract = "Reflecting the greater understanding of the many diverse causes of myocardial injury, international consensus definition of myocardial injury now includes nonischemic causes of myocardial injury and several etiologically distinct subtypes of myocardial infarction (MI). It is time that all ongoing prospective cohorts and clinical trials systematically differentiate and report on all the etiologically distinct types of myocardial injury. Such reporting will undoubtedly advance the fundamental understanding of the epidemiology of myocardial injury events, including differing risk factor associations, allowing better prediction, prevention, and pharmacotherapies for all identified subtypes of myocardial injury events-including all subtypes of MI.",

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AB - Reflecting the greater understanding of the many diverse causes of myocardial injury, international consensus definition of myocardial injury now includes nonischemic causes of myocardial injury and several etiologically distinct subtypes of myocardial infarction (MI). It is time that all ongoing prospective cohorts and clinical trials systematically differentiate and report on all the etiologically distinct types of myocardial injury. Such reporting will undoubtedly advance the fundamental understanding of the epidemiology of myocardial injury events, including differing risk factor associations, allowing better prediction, prevention, and pharmacotherapies for all identified subtypes of myocardial injury events-including all subtypes of MI.

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