TY - JOUR
T1 - Myeloid-derived suppressor cells
T2 - Natural regulators for transplant tolerance
AU - Boros, Peter
AU - Ochando, Jordi C.
AU - Chen, Shu Hsia
AU - Bromberg, Jonathan S.
N1 - Funding Information:
This work was supported by National Institutes of Health grants RO1 AI072039 , RO1 AI41428 , RO1 AI62765 , and JDRFI 1-2008-90 (all to J.S.B.); by the Programa Ramón y Cajal RYC-2006-1588 , Ministerio de Educación y Ciencia SAF2007-63579 , Programa José Castillejo JC2008-00065 , and Programa de Investigación de Grupos Emergentes del ISCIII (to J.C.O.); and by National Institutes of Health grant RO1 CA070337 , CA109322 , CA127483 , Pfizer research found , and Black Family Stem Cell Foundation (to S.H.C.).
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/11
Y1 - 2010/11
N2 - Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed.
AB - Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed.
KW - Myeloid derived suppressor cells
KW - Organ transplantation
KW - Tolerance
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U2 - 10.1016/j.humimm.2010.08.001
DO - 10.1016/j.humimm.2010.08.001
M3 - Review article
C2 - 20705113
AN - SCOPUS:77957754785
VL - 71
SP - 1061
EP - 1066
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 11
ER -