Myeloid-derived suppressor cells: Natural regulators for transplant tolerance

Peter Boros, Jordi C. Ochando, Shu Hsia Chen, Jonathan S. Bromberg

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Myeloid derived suppressor cells (MDSC) contribute to the negative regulation of immune response in cancer patients. This review summarizes results on important issues related to MDSC biology, including expansion and activation of MDSC, phenotype, and subsets as well pathways and different mechanisms by which these cells exert their suppressive effect. Recent observations suggesting that MDSC may have roles in transplant tolerance are presented. Although therapeutic targeting and destruction of MDCS is of primary interest in cancer patients, in transplantation it will instead be necessary to induce, expand, and activate these cells; thus current possibilities for in vitro generation of MDSC are also discussed.

Original languageEnglish (US)
Pages (from-to)1061-1066
Number of pages6
JournalHuman Immunology
Volume71
Issue number11
DOIs
StatePublished - Nov 2010

Keywords

  • Myeloid derived suppressor cells
  • Organ transplantation
  • Tolerance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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