Myeloid-derived suppressor cells in transplantation and cancer

Jordi C. Ochando, Shu Hsia Chen

Research output: Contribution to journalReview article

61 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSC) are myeloid cells that suppress the immune response, a definition that reflects both their origin and their function. As negative regulators of the immune response, MDSC represent a novel therapeutic approach for manipulating the immune system toward tolerance or immunity. MDSC are present in cancer patients and tumor-bearing mice and are in part responsible for the inhibition of the cell-mediated immune response against the tumor. Our laboratories investigate the immunologic mechanisms of tumor acceptance mediated by MDSC, which can be exploited to prevent allograft rejection in transplantation. A better understanding of MDSC biology will open new avenues for therapeutic intervention, either by inhibiting their function (i.e. in cancer patients), or by enhancing their suppressive effects and promoting their expansion (i.e. in organ transplantation and alloimmune responses). In this review, we summarize some of the critical aspects of the immunoregulatory function of MDSC in cancer and transplantation and discuss their potential clinical applications.

Original languageEnglish (US)
Pages (from-to)275-285
Number of pages11
JournalImmunologic Research
Volume54
Issue number1-3
DOIs
StatePublished - Dec 2012

Keywords

  • Cancer
  • MDSC
  • Transplantation

ASJC Scopus subject areas

  • Immunology

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