Myeloid-derived suppressor cells as a trojan horse: A cellular vehicle for the delivery of oncolytic viruses

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We have recently demonstrated that oncolytic vesicular stomatitis viruses can be efficiently and selectively delivered to neoplastic lesions by myeloid-derived suppressor cells (MDSCs). Importantly, the loading of viruses onto MDSCs inhibited their immunosuppressive properties and endowed them with immunostimulatory and tumoricidal functions. Our study demonstrates the potential use of MDSCs as a Trojan horse for the tumor-targeted delivery of various anticancer therapeutics.

Original languageEnglish (US)
Article numbere25083
JournalOncoImmunology
Volume2
Issue number8
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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