Mycobacterium tuberculosis diagnosed promptly by bronchial brushing cytology in an immunocompetent patient

Research output: Contribution to journalArticle

Liye Suo, Tiffany G. Sheu, Suzanne M. Crumley

Respiratory cytology plays an important role in the diagnosis of lower respiratory tract infection. The timely diagnosis of pulmonary tuberculosis (TB) can be very challenging due to the nonspecific cytomorphologic features and limited number of organisms, especially in the immunocompetent patients. Here, we reported a case of TB diagnosed promptly by bronchial brushing cytology in a 51-year-old immunocompetent patient. She presented with a 4 cm fungating lesion involving right lower lobe of the lung and mediastinal lymphadenopathy with an initial concern for malignancy. Bronchial brushing showed scattered acute inflammatory cells in the background of necrosis. A cell block was prepared and acid-fast bacilli (AFB)-positive organisms were identified. Subsequent polymerase chain reaction (PCR) performed on the sputum detected Mycobacterium tuberculosis. This case highlights the importance of recognizing the cytomorphology of TB from a bronchial brushing specimen; and also emphasizes the potential utility of the cell block from respiratory cytology in the diagnosis of TB.

Original languageEnglish (US)
Pages (from-to)368-370
Number of pages3
JournalDiagnostic Cytopathology
Volume48
Issue number4
DOIs
StatePublished - Apr 1 2020

PMID: 31820584

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Mycobacterium tuberculosis diagnosed promptly by bronchial brushing cytology in an immunocompetent patient. / Suo, Liye; Sheu, Tiffany G.; Crumley, Suzanne M.

In: Diagnostic Cytopathology, Vol. 48, No. 4, 01.04.2020, p. 368-370.

Research output: Contribution to journalArticle

Harvard

Suo, L, Sheu, TG & Crumley, SM 2020, 'Mycobacterium tuberculosis diagnosed promptly by bronchial brushing cytology in an immunocompetent patient' Diagnostic Cytopathology, vol. 48, no. 4, pp. 368-370. https://doi.org/10.1002/dc.24367

APA

Suo, L., Sheu, T. G., & Crumley, S. M. (2020). Mycobacterium tuberculosis diagnosed promptly by bronchial brushing cytology in an immunocompetent patient. Diagnostic Cytopathology, 48(4), 368-370. https://doi.org/10.1002/dc.24367

Vancouver

Suo L, Sheu TG, Crumley SM. Mycobacterium tuberculosis diagnosed promptly by bronchial brushing cytology in an immunocompetent patient. Diagnostic Cytopathology. 2020 Apr 1;48(4):368-370. https://doi.org/10.1002/dc.24367

Author

Suo, Liye ; Sheu, Tiffany G. ; Crumley, Suzanne M. / Mycobacterium tuberculosis diagnosed promptly by bronchial brushing cytology in an immunocompetent patient. In: Diagnostic Cytopathology. 2020 ; Vol. 48, No. 4. pp. 368-370.

BibTeX

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title = "Mycobacterium tuberculosis diagnosed promptly by bronchial brushing cytology in an immunocompetent patient",
abstract = "Respiratory cytology plays an important role in the diagnosis of lower respiratory tract infection. The timely diagnosis of pulmonary tuberculosis (TB) can be very challenging due to the nonspecific cytomorphologic features and limited number of organisms, especially in the immunocompetent patients. Here, we reported a case of TB diagnosed promptly by bronchial brushing cytology in a 51-year-old immunocompetent patient. She presented with a 4 cm fungating lesion involving right lower lobe of the lung and mediastinal lymphadenopathy with an initial concern for malignancy. Bronchial brushing showed scattered acute inflammatory cells in the background of necrosis. A cell block was prepared and acid-fast bacilli (AFB)-positive organisms were identified. Subsequent polymerase chain reaction (PCR) performed on the sputum detected Mycobacterium tuberculosis. This case highlights the importance of recognizing the cytomorphology of TB from a bronchial brushing specimen; and also emphasizes the potential utility of the cell block from respiratory cytology in the diagnosis of TB.",
keywords = "acid-fast bacilli, bronchial brushing cytology, cell block, Mycobacterium tuberculosis, polymerase chain reaction",
author = "Liye Suo and Sheu, {Tiffany G.} and Crumley, {Suzanne M.}",
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RIS

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AU - Suo, Liye

AU - Sheu, Tiffany G.

AU - Crumley, Suzanne M.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Respiratory cytology plays an important role in the diagnosis of lower respiratory tract infection. The timely diagnosis of pulmonary tuberculosis (TB) can be very challenging due to the nonspecific cytomorphologic features and limited number of organisms, especially in the immunocompetent patients. Here, we reported a case of TB diagnosed promptly by bronchial brushing cytology in a 51-year-old immunocompetent patient. She presented with a 4 cm fungating lesion involving right lower lobe of the lung and mediastinal lymphadenopathy with an initial concern for malignancy. Bronchial brushing showed scattered acute inflammatory cells in the background of necrosis. A cell block was prepared and acid-fast bacilli (AFB)-positive organisms were identified. Subsequent polymerase chain reaction (PCR) performed on the sputum detected Mycobacterium tuberculosis. This case highlights the importance of recognizing the cytomorphology of TB from a bronchial brushing specimen; and also emphasizes the potential utility of the cell block from respiratory cytology in the diagnosis of TB.

AB - Respiratory cytology plays an important role in the diagnosis of lower respiratory tract infection. The timely diagnosis of pulmonary tuberculosis (TB) can be very challenging due to the nonspecific cytomorphologic features and limited number of organisms, especially in the immunocompetent patients. Here, we reported a case of TB diagnosed promptly by bronchial brushing cytology in a 51-year-old immunocompetent patient. She presented with a 4 cm fungating lesion involving right lower lobe of the lung and mediastinal lymphadenopathy with an initial concern for malignancy. Bronchial brushing showed scattered acute inflammatory cells in the background of necrosis. A cell block was prepared and acid-fast bacilli (AFB)-positive organisms were identified. Subsequent polymerase chain reaction (PCR) performed on the sputum detected Mycobacterium tuberculosis. This case highlights the importance of recognizing the cytomorphology of TB from a bronchial brushing specimen; and also emphasizes the potential utility of the cell block from respiratory cytology in the diagnosis of TB.

KW - acid-fast bacilli

KW - bronchial brushing cytology

KW - cell block

KW - Mycobacterium tuberculosis

KW - polymerase chain reaction

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ID: 60116163