Mycobacterium tuberculosis controls MicroRNA-99b (miR-99b) expression in infected murine dendritic cells to modulate host immunity

Yogesh Singh, Vandana Kaul, Alka Mehra, Samit Chatterjee, Sultan Tousif, Ved Prakash Dwivedi, Mrutyunjay Suar, Luc Van Kaer, William R. Bishai, Gobardhan Das

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Background: Modulation of host miRNAs coincides with increased pathogenicity in various infectious diseases. Results: miR-99b is up-regulated in M. tuberculosis-infected dendritic cells, which inhibits production of proinflammatory cytokines. Conclusion: Our findings unfold a novel immune evasion strategy of M. tuberculosis by modulating miRNAs. Significance: Our study opens up the possibility to design vaccines and immunotherapies for tuberculosis by targeting specific miRNAs.

Original languageEnglish (US)
Pages (from-to)5056-5061
Number of pages6
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - Feb 15 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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