Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori

James Versalovic, Dee Shortridge, Kirsten Kibler, Mamie V. Griffy, Jill Beyer, Robert K. Flamm, S. Ken Tanaka, David Y. Graham, Mae F. Go

Research output: Contribution to journalArticle

407 Scopus citations

Abstract

Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A→G transition mutation within a conserved loop of 23S rRNA. A→G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin-susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens.

Original languageEnglish (US)
Pages (from-to)477-480
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume40
Issue number2
DOIs
StatePublished - Feb 1996

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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