Abstract
Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A→G transition mutation within a conserved loop of 23S rRNA. A→G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin-susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens.
Original language | English (US) |
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Pages (from-to) | 477-480 |
Number of pages | 4 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 40 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1996 |
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases