TY - JOUR
T1 - Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
AU - Rawlings, David J.
AU - Saffran, Douglas C.
AU - Tsukada, Satoshi
AU - Largaespada, David A.
AU - Grimaldi, J. Christopher
AU - Cohen, Lucie
AU - Mohr, Randolph N.
AU - Bazan, J. Fernando
AU - Howard, Maureen
AU - Copeland, Neal G.
AU - Jenkins, Nancy A.
AU - Witte, Owen N.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1993
Y1 - 1993
N2 - The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.
AB - The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.
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U2 - 10.1126/science.8332901
DO - 10.1126/science.8332901
M3 - Article
C2 - 8332901
AN - SCOPUS:0027305921
VL - 261
SP - 358
EP - 361
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 5119
ER -