Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

David J. Rawlings; Douglas C. Saffran; Satoshi Tsukada; David A. Largaespada; J. Christopher Grimaldi; Lucie Cohen; Randolph N. Mohr; J. Fernando Bazan; Maureen Howard; Neal G. Copeland; Nancy A. Jenkins; Owen N. Witte

doi:10.1126/science.8332901

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

David J. Rawlings, Douglas C. Saffran, Satoshi Tsukada, David A. Largaespada, J. Christopher Grimaldi, Lucie Cohen, Randolph N. Mohr, J. Fernando Bazan, Maureen Howard, Neal G. Copeland, Nancy A. Jenkins, Owen N. Witte

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Abstract

The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.

Original language	English (US)
Pages (from-to)	358-361
Number of pages	4
Journal	Science
Volume	261
Issue number	5119
DOIs	https://doi.org/10.1126/science.8332901
State	Published - 1993

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@article{198557718db3493782e51492022bf4e8,

title = "Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice",

abstract = "The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.",

author = "Rawlings, {David J.} and Saffran, {Douglas C.} and Satoshi Tsukada and Largaespada, {David A.} and Grimaldi, {J. Christopher} and Lucie Cohen and Mohr, {Randolph N.} and Bazan, {J. Fernando} and Maureen Howard and Copeland, {Neal G.} and Jenkins, {Nancy A.} and Witte, {Owen N.}",

year = "1993",

doi = "10.1126/science.8332901",

language = "English (US)",

volume = "261",

pages = "358--361",

journal = "Science (New York, N.Y.)",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5119",

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T1 - Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

AU - Rawlings, David J.

AU - Saffran, Douglas C.

AU - Tsukada, Satoshi

AU - Largaespada, David A.

AU - Grimaldi, J. Christopher

AU - Cohen, Lucie

AU - Mohr, Randolph N.

AU - Bazan, J. Fernando

AU - Howard, Maureen

AU - Copeland, Neal G.

AU - Jenkins, Nancy A.

AU - Witte, Owen N.

PY - 1993

Y1 - 1993

N2 - The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.

AB - The cytoplasmic tyrosine kinase, Bruton's tyrosine kinase (Btk, formerly bpk or atk), is crucial for B cell development. Loss of kinase activity results in the human immunodeficiency, X-linked agammaglobulinemia, characterized by a failure to produce B cells. In the murine X-linked immunodeficiency (XID), B cells are present but respond abnormally to activating signals. The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis. A single conserved residue within the amino terminal unique region of Btk was mutated in XID mice. This change in xid probably interferes with normal B cell signaling mediated by Btk protein interactions.

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JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

SN - 0036-8075

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ER -

Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

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