The presumed halothane metabolite, 2-bromo-2-chloro-1, 1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtilis transformation assay to score the production of mutagenic lesions in transforming DNA.
ASJC Scopus subject areas
- Environmental Science(all)
- Environmental Chemistry
- Public Health, Environmental and Occupational Health