Mutagenicity of the halogenated olefin, 2 bromo 2 chloro 1, 1 difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

A. J. Garro, R. A. Phillips

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The presumed halothane metabolite, 2-bromo-2-chloro-1, 1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtilis transformation assay to score the production of mutagenic lesions in transforming DNA.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalEnvironmental health perspectives
VolumeVol. 21
DOIs
StatePublished - 1977

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

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