Mutagenicity of the halogenated olefin, 2 bromo 2 chloro 1, 1 difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

A. J. Garro; R. A. Phillips

doi:10.1289/ehp.772165

Mutagenicity of the halogenated olefin, 2 bromo 2 chloro 1, 1 difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

A. J. Garro, R. A. Phillips

Research output: Contribution to journal › Article › peer-review

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Abstract

The presumed halothane metabolite, 2-bromo-2-chloro-1, 1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtilis transformation assay to score the production of mutagenic lesions in transforming DNA.

Original language	English (US)
Pages (from-to)	65-69
Number of pages	5
Journal	Environmental health perspectives
Volume	Vol. 21
DOIs	https://doi.org/10.1289/ehp.772165
State	Published - 1977

ASJC Scopus subject areas

Environmental Science(all)
Environmental Chemistry
Public Health, Environmental and Occupational Health

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@article{1be29b9f154742ff906d24f7cc0caf89,

title = "Mutagenicity of the halogenated olefin, 2 bromo 2 chloro 1, 1 difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane",

abstract = "The presumed halothane metabolite, 2-bromo-2-chloro-1, 1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtilis transformation assay to score the production of mutagenic lesions in transforming DNA.",

author = "Garro, {A. J.} and Phillips, {R. A.}",

note = "Funding Information: This investigatiown as supportedb y researchg rantsN o. BC-200 from the American Cancer Society and CA22354 from the N.I.H. The authorst hank Ms. V. Lima for her technicaal ssistancaen dthe chemistas t ColumbiaO rganic Chemicalas ndPCR for theirh elpfuld iscussions.",

year = "1977",

doi = "10.1289/ehp.772165",

language = "English (US)",

volume = "Vol. 21",

pages = "65--69",

journal = "Environmental health perspectives",

issn = "0091-6765",

publisher = "Public Health Services, US Dept of Health and Human Services",

}

TY - JOUR

T1 - Mutagenicity of the halogenated olefin, 2 bromo 2 chloro 1, 1 difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

AU - Garro, A. J.

AU - Phillips, R. A.

N1 - Funding Information: This investigatiown as supportedb y researchg rantsN o. BC-200 from the American Cancer Society and CA22354 from the N.I.H. The authorst hank Ms. V. Lima for her technicaal ssistancaen dthe chemistas t ColumbiaO rganic Chemicalas ndPCR for theirh elpfuld iscussions.

PY - 1977

Y1 - 1977

N2 - The presumed halothane metabolite, 2-bromo-2-chloro-1, 1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtilis transformation assay to score the production of mutagenic lesions in transforming DNA.

AB - The presumed halothane metabolite, 2-bromo-2-chloro-1, 1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtilis transformation assay to score the production of mutagenic lesions in transforming DNA.

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U2 - 10.1289/ehp.772165

DO - 10.1289/ehp.772165

M3 - Article

C2 - 417917

AN - SCOPUS:0017621618

SN - 0091-6765

VL - Vol. 21

SP - 65

EP - 69

JO - Environmental health perspectives

JF - Environmental health perspectives

ER -

Mutagenicity of the halogenated olefin, 2 bromo 2 chloro 1, 1 difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane

Abstract

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