TY - JOUR
T1 - Mutagenic potential of binary mixtures of n1tro-polychlorinated dibenzo-p-dioxins and related compounds
AU - Donnelly, K. C.
AU - Brown, K. W.
AU - Estiri, M.
AU - Jones, D. H.
AU - Safe, S.
PY - 1988/7
Y1 - 1988/7
N2 - The mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p- dioxins and other environmentally related compounds was determined using Salmonella typhimurium strain TA98 in the standard plate incorporation assay. Samples tested included binary mixtures of 4-nitro-4’-chlorobiphenyl with G-nitro-4, 2’, 3’, 4’, 5’ - pentachlorobiphenyl, 4-nitrobenzo-p-dioxin with 4-nitro-2, 3, 8-trichlorodibenzo-p- dioxin, and benzo[a]pyrene with either nitropentachlorobiphenyl or nitrotrichlorodibenzo-p-dioxin. Inhibition was the primary interaction observed for the mixtures of polyhalogenated dioxins or biphenyls with the direct-acting mutagens nitrodibenzo-p-dioxin or nitrochlorobiphenyl. At the highest dose tested, nitrotrichlroodibenzo-p-dioxin or nitrochlorobiphenyl. At the highest dose tested, nitrotrichlorodibenzo-p-dioxin inhibited the bacterial mutagenicity of nitrodibenzo-p- dioxin by almost 50%, while pentachlorobiphenyl inhibited the mutagenicity of nitro- biphenyl by 34%. Conversely, synergism was the primary interaction observed for mixtures of halogenated aromatics with the promutagen benzo[a]pyrene. The addition of nitrotrichlorodioxin to benzo[a]pyrene enhanced the mutagenicity of the latter compound by as much as 70%, while the mutagenic potential of a mixture of ben- zo[a]pyrene and nitropentachlorobiphenyl was approximately 50% greater than the mutagenicity of benzo[a]pyrene alone. In summary, mixtures of nonmutagenic nitro- polyhalogenated biphenyls or dibenzo-p-dioxins appear to inhibit the mutagenicity of direct-acting mutagens, while these same compounds seem to enhance the mutagenic potential of the promutagen benzo[a]pyrene.
AB - The mutagenic potential of binary mixtures of nitro-polychlorinated dibenzo-p- dioxins and other environmentally related compounds was determined using Salmonella typhimurium strain TA98 in the standard plate incorporation assay. Samples tested included binary mixtures of 4-nitro-4’-chlorobiphenyl with G-nitro-4, 2’, 3’, 4’, 5’ - pentachlorobiphenyl, 4-nitrobenzo-p-dioxin with 4-nitro-2, 3, 8-trichlorodibenzo-p- dioxin, and benzo[a]pyrene with either nitropentachlorobiphenyl or nitrotrichlorodibenzo-p-dioxin. Inhibition was the primary interaction observed for the mixtures of polyhalogenated dioxins or biphenyls with the direct-acting mutagens nitrodibenzo-p-dioxin or nitrochlorobiphenyl. At the highest dose tested, nitrotrichlroodibenzo-p-dioxin or nitrochlorobiphenyl. At the highest dose tested, nitrotrichlorodibenzo-p-dioxin inhibited the bacterial mutagenicity of nitrodibenzo-p- dioxin by almost 50%, while pentachlorobiphenyl inhibited the mutagenicity of nitro- biphenyl by 34%. Conversely, synergism was the primary interaction observed for mixtures of halogenated aromatics with the promutagen benzo[a]pyrene. The addition of nitrotrichlorodioxin to benzo[a]pyrene enhanced the mutagenicity of the latter compound by as much as 70%, while the mutagenic potential of a mixture of ben- zo[a]pyrene and nitropentachlorobiphenyl was approximately 50% greater than the mutagenicity of benzo[a]pyrene alone. In summary, mixtures of nonmutagenic nitro- polyhalogenated biphenyls or dibenzo-p-dioxins appear to inhibit the mutagenicity of direct-acting mutagens, while these same compounds seem to enhance the mutagenic potential of the promutagen benzo[a]pyrene.
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U2 - 10.1080/15287398809531166
DO - 10.1080/15287398809531166
M3 - Article
C2 - 3398076
AN - SCOPUS:0023782404
VL - 24
SP - 345
EP - 356
JO - Journal of Toxicology and Environmental Health
JF - Journal of Toxicology and Environmental Health
SN - 0098-4108
IS - 3
ER -