Murine model of infection by Tropheryma whipplei

Séverine Genot; Andreas Stein; Hubert Lepidi; Melanie Ihrig; Didier Raoult; Jean Louis Mege

doi:10.1128/IAI.00283-06

Murine model of infection by Tropheryma whipplei

Séverine Genot, Andreas Stein, Hubert Lepidi, Melanie Ihrig, Didier Raoult, Jean Louis Mege

Houston Methodist

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.

Original language	English (US)
Pages (from-to)	4915-4917
Number of pages	3
Journal	Infection and Immunity
Volume	74
Issue number	8
DOIs	https://doi.org/10.1128/IAI.00283-06
State	Published - Aug 2006

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.00283-06

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abstract = "We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.",

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AU - Mege, Jean Louis

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AB - We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.

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Murine model of infection by Tropheryma whipplei

Abstract

ASJC Scopus subject areas

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