Murine model of infection by Tropheryma whipplei

Séverine Genot, Andreas Stein, Hubert Lepidi, Melanie Ihrig, Didier Raoult, Jean Louis Mege

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei, its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.

Original languageEnglish (US)
Pages (from-to)4915-4917
Number of pages3
JournalInfection and Immunity
Issue number8
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases


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