TY - JOUR
T1 - Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors
AU - Avraham, Karen B.
AU - Fletcher, Colin
AU - Overdier, David G.
AU - Clevidence, Derek E.
AU - Lai, Eseng
AU - Costa, Robert H.
AU - Jenkins, Nancy A.
AU - Copeland, Neal G.
N1 - Funding Information:
We thank D. J. Gilbert, D. Swing, M. Barnstead, and D. Barnhart for excellent technical assistance. This research was supported, in part, by the National Cancer Institute, DHHS, under Contract NOl-CO-74101 with ABL. This research was also supported, in part, by a grant from the Council for Tobacco Research (2822) to R.H.C. and by the American Cancer Society to E.L. K.B.A. is supported by the National Institutes of Health, National Research Service Award 5F32GM15909-02 from the National Institute of General Medical Sciences. R.H.C. is an Established Investiaator of the American Heart Association/Bristol-Myers Squibb.
PY - 1995
Y1 - 1995
N2 - A 100-amino-acid DNA-binding motif, known as the winged helix, was first identified in the mammalian hepatocyte nuclear factor-3 (HNF-3) and Drosophila fork head family of transcription factors. Subsequently, more than 40 different genes that contain the winged helix motif have been identified. In the studies described here, we have determined the murine chromosomal location of eight members of this gene family, HFH-1, HFH-3, HFH-4, HFH-5, HFH-6, HFH-8, BF-1, and BF-2, by interspecific backcross analysis. These genes, designated HNF-3 fork head homolog 1 (Hfh1), Hfh3, Hfh4, Hfh5, Hfh6, Hfh8, Hfh9, and Hfh10, respectively, mapped to 6 different mouse autosomes and are thus well dispersed throughout the mouse genome. Based on this mapping information, we predict the chromosomal location of these genes in humans and discuss the potential of these genes as candidates for uncloned mouse mutations.
AB - A 100-amino-acid DNA-binding motif, known as the winged helix, was first identified in the mammalian hepatocyte nuclear factor-3 (HNF-3) and Drosophila fork head family of transcription factors. Subsequently, more than 40 different genes that contain the winged helix motif have been identified. In the studies described here, we have determined the murine chromosomal location of eight members of this gene family, HFH-1, HFH-3, HFH-4, HFH-5, HFH-6, HFH-8, BF-1, and BF-2, by interspecific backcross analysis. These genes, designated HNF-3 fork head homolog 1 (Hfh1), Hfh3, Hfh4, Hfh5, Hfh6, Hfh8, Hfh9, and Hfh10, respectively, mapped to 6 different mouse autosomes and are thus well dispersed throughout the mouse genome. Based on this mapping information, we predict the chromosomal location of these genes in humans and discuss the potential of these genes as candidates for uncloned mouse mutations.
UR - http://www.scopus.com/inward/record.url?scp=0028922032&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028922032&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(95)80038-N
DO - 10.1016/0888-7543(95)80038-N
M3 - Article
C2 - 7789972
AN - SCOPUS:0028922032
SN - 0888-7543
VL - 25
SP - 388
EP - 393
JO - Genomics
JF - Genomics
IS - 2
ER -