Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors

Karen B. Avraham, Colin Fletcher, David G. Overdier, Derek E. Clevidence, Eseng Lai, Robert H. Costa, Nancy A. Jenkins, Neal G. Copeland

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A 100-amino-acid DNA-binding motif, known as the winged helix, was first identified in the mammalian hepatocyte nuclear factor-3 (HNF-3) and Drosophila fork head family of transcription factors. Subsequently, more than 40 different genes that contain the winged helix motif have been identified. In the studies described here, we have determined the murine chromosomal location of eight members of this gene family, HFH-1, HFH-3, HFH-4, HFH-5, HFH-6, HFH-8, BF-1, and BF-2, by interspecific backcross analysis. These genes, designated HNF-3 fork head homolog 1 (Hfh1), Hfh3, Hfh4, Hfh5, Hfh6, Hfh8, Hfh9, and Hfh10, respectively, mapped to 6 different mouse autosomes and are thus well dispersed throughout the mouse genome. Based on this mapping information, we predict the chromosomal location of these genes in humans and discuss the potential of these genes as candidates for uncloned mouse mutations.

Original languageEnglish (US)
Pages (from-to)388-393
Number of pages6
JournalGenomics
Volume25
Issue number2
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Genetics

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