Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children

J. Chase McNeil; Kristina G. Hulten; Sheldon L. Kaplan; Edward O. Mason

doi:10.1128/AAC.01587-10

Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children

J. Chase McNeil, Kristina G. Hulten, Sheldon L. Kaplan, Edward O. Mason

Research Institute

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42 Scopus citations

Abstract

Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carried mupA, and the gene was more common in methicillin-susceptible S. aureus (21.4%) than methicillin-resistant S. aureus (8.3%; P = 0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.

Original language	English (US)
Pages (from-to)	2431-2433
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	5
DOIs	https://doi.org/10.1128/AAC.01587-10
State	Published - May 2011

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carried mupA, and the gene was more common in methicillin-susceptible S. aureus (21.4%) than methicillin-resistant S. aureus (8.3%; P = 0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.",

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