Mupirocin resistance in Staphylococcus aureus causing recurrent skin and soft tissue infections in children

J. Chase McNeil, Kristina G. Hulten, Sheldon L. Kaplan, Edward O. Mason

    Research output: Contribution to journalArticlepeer-review

    55 Scopus citations

    Abstract

    Staphylococcus aureus resistance to mupirocin is often caused by acquisition of a novel isoleucyl-tRNA synthetase encoded on the plasmid gene mupA. We tested S. aureus isolates from children at Texas Children's Hospital with recurrent skin and soft tissue infections for mupirocin resistance and mupA. Of 136 isolates, 20 were resistant to mupirocin (14.7%). Fifteen isolates (11%) carried mupA, and the gene was more common in methicillin-susceptible S. aureus (21.4%) than methicillin-resistant S. aureus (8.3%; P = 0.03). Seven of 20 mupirocin-resistant isolates displayed clindamycin resistance.

    Original languageEnglish (US)
    Pages (from-to)2431-2433
    Number of pages3
    JournalAntimicrobial Agents and Chemotherapy
    Volume55
    Issue number5
    DOIs
    StatePublished - May 2011

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)
    • Infectious Diseases

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