TY - JOUR
T1 - Multisite Detection of Tn1549-Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida
AU - Simar, Shelby R.
AU - Tran, Truc T.
AU - Rydell, Kirsten B.
AU - Panesso, Diana
AU - Contreras, German A.
AU - Munita, Jose M.
AU - Cifuentes, Renzo O.
AU - Abbo, Lilian M.
AU - Sahasrabhojane, Pranoti
AU - Dinh, An Q.
AU - Axell-House, Dierdre B.
AU - Savidge, Tor
AU - Shelburne, Samuel A.
AU - Hanson, Blake M.
AU - Arias, Cesar A.
N1 - Funding Information:
Copyright © 2022 American Society for Microbiology. All Rights Reserved. Address correspondence to Cesar A. Arias, [email protected], or Blake M. Hanson, [email protected]. The authors declare a conflict of interest. C.A.A. has received grant support from MeMed Diagnostics, Merck Pharmaceuticals, and Entasis Pharmaceuticals. Received 21 September 2022 Returned for modification 25 October 2022 Accepted 1 December 2022 Published 21 December 2022
Funding Information:
This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID) K24AI121296, R01AI134637, R01AI148342-01, P01AI152999-01 to C.A.A. S.R.S. was partially funded under National Institutes of Health (NIH) pre-doctoral training grant (5T32AI055449-15 to Theresa M. Koehler/Michael Lorenz). B.M.H. was supported by NIAID K01AI148593-01 and P01AI152999-01.
Publisher Copyright:
© 2022 American Society for Microbiology. All Rights Reserved.
PY - 2023/1/24
Y1 - 2023/1/24
N2 - In the United States, vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.
AB - In the United States, vanB-mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.
KW - Enterococcus
KW - VRE
KW - antimicrobial resistance
KW - Humans
KW - Vancomycin-Resistant Enterococci/genetics
KW - Anti-Bacterial Agents/pharmacology
KW - Enterococcus faecium
KW - Texas/epidemiology
KW - Bacterial Proteins/genetics
KW - Vancomycin Resistance/genetics
KW - Enterococcus faecalis/genetics
KW - Florida/epidemiology
KW - Gram-Positive Bacterial Infections/drug therapy
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U2 - 10.1128/aac.01284-22
DO - 10.1128/aac.01284-22
M3 - Article
C2 - 36541772
AN - SCOPUS:85147047842
SN - 0066-4804
VL - 67
SP - e0128422
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
ER -