Multiscale models for transport and biodistribution of therapeutics in cancer

Arturas Ziemys, Milos Kojic, Miljan Milosevic, Bernhard Schrefler, Mauro Ferrari

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The chapter discusses the computational framework dedicated to simulate time-dependent biodistribution with focus on cancer. While systemic pharmacokinetic and biodistribution problems are extensively studied, the factors considered here are drug transport from drug vectors, drug transport and biodistribution in the tumor microenvironment, whole organ, and including the biodistribution effect on tumor growth. Continuum-based computational strategies are presented. Selected example solutions demonstrate the applicability of this methodology to in vitro and in vivo conditions.

Original languageEnglish (US)
Title of host publicationComputer Aided Chemical Engineering
EditorsDavide Manca
PublisherElsevier B.V.
Pages209-237
Number of pages29
ISBN (Print)9780444639646
DOIs
StatePublished - Jan 1 2018

Publication series

NameComputer Aided Chemical Engineering
Volume42
ISSN (Print)1570-7946

Keywords

  • Convection
  • Diffusion
  • Doxorubicin
  • Finite element method
  • Molecular dynamics
  • Pharmacokinetics
  • Tumor microenvironment

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Computer Science Applications

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