Multiscale models for transport and biodistribution of therapeutics in cancer

Arturas Ziemys; Milos Kojic; Miljan Milosevic; Bernhard Schrefler; Mauro Ferrari

doi:10.1016/B978-0-444-63964-6.00007-6

Multiscale models for transport and biodistribution of therapeutics in cancer

Arturas Ziemys, Milos Kojic, Miljan Milosevic, Bernhard Schrefler, Mauro Ferrari

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The chapter discusses the computational framework dedicated to simulate time-dependent biodistribution with focus on cancer. While systemic pharmacokinetic and biodistribution problems are extensively studied, the factors considered here are drug transport from drug vectors, drug transport and biodistribution in the tumor microenvironment, whole organ, and including the biodistribution effect on tumor growth. Continuum-based computational strategies are presented. Selected example solutions demonstrate the applicability of this methodology to in vitro and in vivo conditions.

Original language	English (US)
Title of host publication	Computer Aided Chemical Engineering
Editors	Davide Manca
Publisher	Elsevier B.V.
Pages	209-237
Number of pages	29
ISBN (Print)	9780444639646
DOIs	https://doi.org/10.1016/B978-0-444-63964-6.00007-6
State	Published - Jan 1 2018

Publication series

Name	Computer Aided Chemical Engineering
Volume	42
ISSN (Print)	1570-7946

Keywords

Convection
Diffusion
Doxorubicin
Finite element method
Molecular dynamics
Pharmacokinetics
Tumor microenvironment

ASJC Scopus subject areas

Chemical Engineering(all)
Computer Science Applications

Access to Document

10.1016/B978-0-444-63964-6.00007-6

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Multiscale models for transport and biodistribution of therapeutics in cancer. / Ziemys, Arturas ; Kojic, Milos; Milosevic, Miljan; Schrefler, Bernhard; Ferrari, Mauro.

Computer Aided Chemical Engineering. ed. / Davide Manca. Elsevier B.V., 2018. p. 209-237 (Computer Aided Chemical Engineering; Vol. 42).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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