TY - JOUR
T1 - Multiscale modeling of circular and elliptical particles in laminar shear flow
AU - Filipovic, Nenad
AU - Isailović, Velibor
AU - Dukić, Tijana
AU - Ferrari, Mauro
AU - Kojic, Milos
N1 - Funding Information:
Manuscript received April 2, 2011; revised June 12, 2011; accepted August 13, 2011. Date of publication August 30, 2011; date of current version December 21, 2011. This work was supported by The Methodist Hospital Research Institute, Houston, TX. Asterisk indicates corresponding author. *N. Filipovic and T. -Dukić are with the University of Kragujevac, Kragujevac 34000, Serbia (e-mail: [email protected]; [email protected]). V. Isailović is with Bioengineering R&D Center, Bioengineering Research and Development Center, Kragujevac 34000, Serbia (e-mail: [email protected]). M. Ferrari and M. Kojic are with The Methodist Hospital Research Institute, Houston, TX 77030 USA (e-mail: [email protected]; mkojic@hsph. harvard.edu). Color versions of one or more of the figures in this paper are available online at http://ieeexplore.ieee.org. Digital Object Identifier 10.1109/TBME.2011.2166264
PY - 2012/1
Y1 - 2012/1
N2 - Drug delivery systems for cancer prevention and pain management have been improved related to classical cancer chemotherapy. Nanotechnology with nanoparticles offers new ways in transport of drug molecules and contrast agents by the blood flow through the circulatory system. In this study, we use multiscale mesoscopic bridging procedure of the finite elements (FE) coupled with dissipative particle dynamics (DPD) and lattice Boltzmann (LB) method to model the motion of circular and elliptical particles in a 2-D laminar flow. Four examples are considered: 1) one sedimenting cylinder in a channel, 2) two sedimenting cylinders in a channel, 3) motion of four elliptical particles in a linear shear flow, and 4) motion of circular and elliptical particle in the arterial bifurcation geometry. A good agreement with solution from the literature available was found. These results show that the multiscale approach with coupled FE and DPD/LB methods can effectively be applied to model motion of micro/nanoparticles for a drug delivery system.
AB - Drug delivery systems for cancer prevention and pain management have been improved related to classical cancer chemotherapy. Nanotechnology with nanoparticles offers new ways in transport of drug molecules and contrast agents by the blood flow through the circulatory system. In this study, we use multiscale mesoscopic bridging procedure of the finite elements (FE) coupled with dissipative particle dynamics (DPD) and lattice Boltzmann (LB) method to model the motion of circular and elliptical particles in a 2-D laminar flow. Four examples are considered: 1) one sedimenting cylinder in a channel, 2) two sedimenting cylinders in a channel, 3) motion of four elliptical particles in a linear shear flow, and 4) motion of circular and elliptical particle in the arterial bifurcation geometry. A good agreement with solution from the literature available was found. These results show that the multiscale approach with coupled FE and DPD/LB methods can effectively be applied to model motion of micro/nanoparticles for a drug delivery system.
KW - 2-D laminar shear flow
KW - Dissipative particle dynamics (DPD)
KW - finite element (FE)
KW - Lattice Boltzmann (LB) methods
KW - margination
KW - multiscale mesoscopic bridging
KW - nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84555202612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84555202612&partnerID=8YFLogxK
U2 - 10.1109/TBME.2011.2166264
DO - 10.1109/TBME.2011.2166264
M3 - Article
C2 - 21878403
AN - SCOPUS:84555202612
SN - 0018-9294
VL - 59
SP - 50
EP - 53
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 1
M1 - 6003766
ER -