TY - JOUR
T1 - MULTISCALE COMPOSITE 3D FINITE ELEMENT FOR LUNG MECHANICS
AU - Kojic, M.
N1 - Funding Information:
The author acknowledges support from the City of Kragujevac, Serbia, Ministry of Education and Science of Serbia (grants OI 174028 and III 41007) and from National Cancer Institute under grant U54 CA210187. This work is supported by the SILICOFCM project that has received funding from the European Union?s Horizon 2020 research and innovation programme under grant agreement No 777204. The author is thankful to Dr. Akira Tsuda, Harvard School of Public Health, (retired), for very useful discussion and suggestions during this work.
Funding Information:
The author acknowledges support from the City of Kragujevac, Serbia, Ministry of Education and Science of Serbia (grants OI 174028 and III 41007) and from National Cancer Institute under grant U54 CA210187. This work is supported by the SILICOFCM project that has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 777204.
Publisher Copyright:
© 2020. All Rights Reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - The lungs are the pair of organs where very complex internal microstructure provides gas exchange as the vital process of living organisms. This exchange in humans occurs within only 300g of tissue but on the surface of millions of alveoli with the total surface area of around 130m2. The extremely complex microstructure consists of micron-size interconnected channels and alveoli, which significantly change the size during breathing and remain open. These conditions are maintained due to existence of two mechanical systems – one external and the other internal, which act in the opposite sense, so that the lung behaves as a tensegrity system. Many computational models, with various degrees of simplifications and sophistication have been introduced. However, this task remains a challenge. We here introduce a 3D multi-scale composite FE for mechanics of lung tissue (MSCL). The model can be further used in generating computational models for mechanics for the entire lung and coupling to airflow.
AB - The lungs are the pair of organs where very complex internal microstructure provides gas exchange as the vital process of living organisms. This exchange in humans occurs within only 300g of tissue but on the surface of millions of alveoli with the total surface area of around 130m2. The extremely complex microstructure consists of micron-size interconnected channels and alveoli, which significantly change the size during breathing and remain open. These conditions are maintained due to existence of two mechanical systems – one external and the other internal, which act in the opposite sense, so that the lung behaves as a tensegrity system. Many computational models, with various degrees of simplifications and sophistication have been introduced. However, this task remains a challenge. We here introduce a 3D multi-scale composite FE for mechanics of lung tissue (MSCL). The model can be further used in generating computational models for mechanics for the entire lung and coupling to airflow.
KW - lung tissue material models
KW - mechanics of lung microstructure
KW - multi-scale 3D composite finite element
KW - surfactant
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U2 - 10.24874/jsscm.2020.14.01.01
DO - 10.24874/jsscm.2020.14.01.01
M3 - Article
AN - SCOPUS:85101812041
VL - 14
SP - 1
EP - 11
JO - Journal of the Serbian Society for Computational Mechanics
JF - Journal of the Serbian Society for Computational Mechanics
SN - 1820-6530
IS - 1
ER -