Multiscale agent-based cancer modeling

Le Zhang, Zhihui Wang, Jonathan A. Sagotsky, Thomas S. Deisboeck

Research output: Contribution to journalReview article

99 Scopus citations

Abstract

Agent-based modeling (ABM) is an in silico technique that is being used in a variety of research areas such as in social sciences, economics and increasingly in biomedicine as an interdisciplinary tool to study the dynamics of complex systems. Here, we describe its applicability to integrative tumor biology research by introducing a multi-scale tumor modeling platform that understands brain cancer as a complex dynamic biosystem. We summarize significant findings of this work, and discuss both challenges and future directions for ABM in the field of cancer research.

Original languageEnglish (US)
Pages (from-to)545-559
Number of pages15
JournalJournal of Mathematical Biology
Volume58
Issue number4-5
DOIs
StatePublished - Apr 1 2009

Keywords

  • Agent-based modeling
  • Computational systems biology
  • Tumor simulation

ASJC Scopus subject areas

  • Modeling and Simulation
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics

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