TY - JOUR
T1 - Multiple sclerosis lesion geometry in quantitative susceptibility mapping (QSM) and phase imaging
AU - Eskreis-Winkler, Sarah
AU - Deh, Kofi
AU - Gupta, Ajay
AU - Liu, Tian
AU - Wisnieff, Cynthia
AU - Jin, Moonsoo
AU - Gauthier, Susan A.
AU - Wang, Yi
AU - Spincemaille, Pascal
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2015/7/1
Y1 - 2015/7/1
N2 - Purpose To demonstrate the phase and quantitative susceptibility mapping (QSM) patterns created by solid and shell spatial distributions of magnetic susceptibility in multiple sclerosis (MS) lesions. Materials and Methods Numerical simulations and experimental phantoms of solid- and shell-shaped magnetic susceptibility sources were used to generate magnitude, phase, and QSM images. Imaging of 20 consecutive MS patients was also reviewed for this Institutional Review Board (IRB)-approved MRI study to identify the appearance of solid and shell lesions on phase and QSM images. Results Solid and shell susceptibility sources were correctly reconstructed in QSM images, while the corresponding phase images depicted both geometries with shell-like patterns, making the underlying susceptibility distribution difficult to determine using phase alone. In MS patients, of the 60 largest lesions identified on T2, 30 lesions were detected on both QSM and phase, of which 83% were solid and 17% were shells on QSM, and of which 30% were solid and 70% were shell on phase. Of the 21 shell-like lesions on phase, 76% appeared solid on QSM, 24% appeared shell on QSM. Of the five shell-like lesions on QSM, all were shell-like on phase. Conclusion QSM accurately depicts both solid and shell patterns of magnetic susceptibility, while phase imaging fails to distinguish them.
AB - Purpose To demonstrate the phase and quantitative susceptibility mapping (QSM) patterns created by solid and shell spatial distributions of magnetic susceptibility in multiple sclerosis (MS) lesions. Materials and Methods Numerical simulations and experimental phantoms of solid- and shell-shaped magnetic susceptibility sources were used to generate magnitude, phase, and QSM images. Imaging of 20 consecutive MS patients was also reviewed for this Institutional Review Board (IRB)-approved MRI study to identify the appearance of solid and shell lesions on phase and QSM images. Results Solid and shell susceptibility sources were correctly reconstructed in QSM images, while the corresponding phase images depicted both geometries with shell-like patterns, making the underlying susceptibility distribution difficult to determine using phase alone. In MS patients, of the 60 largest lesions identified on T2, 30 lesions were detected on both QSM and phase, of which 83% were solid and 17% were shells on QSM, and of which 30% were solid and 70% were shell on phase. Of the 21 shell-like lesions on phase, 76% appeared solid on QSM, 24% appeared shell on QSM. Of the five shell-like lesions on QSM, all were shell-like on phase. Conclusion QSM accurately depicts both solid and shell patterns of magnetic susceptibility, while phase imaging fails to distinguish them.
KW - iron
KW - multiple sclerosis
KW - phase
KW - quantitative susceptibility mapping
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U2 - 10.1002/jmri.24745
DO - 10.1002/jmri.24745
M3 - Article
C2 - 25174493
AN - SCOPUS:84931837123
VL - 42
SP - 224
EP - 229
JO - Journal of Magnetic Resonance Imaging
JF - Journal of Magnetic Resonance Imaging
SN - 1053-1807
IS - 1
ER -