Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Aidan McGowan; Julie Y. An; Sally Tanakchi; Mahir Maruf; Akhil Muthigi; Arvin George; Daniel Su; Maria J. Merino; W. Marston Linehan; Shawna L. Boyle; Adam R. Metwalli

doi:10.1016/j.eucr.2017.03.017

Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Aidan McGowan, Julie Y. An, Sally Tanakchi, Mahir Maruf, Akhil Muthigi, Arvin George, Daniel Su, Maria J. Merino, W. Marston Linehan, Shawna L. Boyle, Adam R. Metwalli

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.

Original language	English (US)
Pages (from-to)	107-109
Number of pages	3
Journal	Urology case reports
Volume	13
DOIs	https://doi.org/10.1016/j.eucr.2017.03.017
State	Published - Jul 1 2017

Keywords

Adrenalectomy
Nephrectomy
Paraganglioma
Succinate dehydrogenase B mutation

ASJC Scopus subject areas

Urology

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10.1016/j.eucr.2017.03.017

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@article{7336f47dec2a4f71b116173baf3d0d03,

title = "Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation",

abstract = "Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.",

keywords = "Adrenalectomy, Nephrectomy, Paraganglioma, Succinate dehydrogenase B mutation",

author = "Aidan McGowan and An, \{Julie Y.\} and Sally Tanakchi and Mahir Maruf and Akhil Muthigi and Arvin George and Daniel Su and Merino, \{Maria J.\} and Linehan, \{W. Marston\} and Boyle, \{Shawna L.\} and Metwalli, \{Adam R.\}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = jul,

day = "1",

doi = "10.1016/j.eucr.2017.03.017",

language = "English (US)",

volume = "13",

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T1 - Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

AU - McGowan, Aidan

AU - An, Julie Y.

AU - Tanakchi, Sally

AU - Maruf, Mahir

AU - Muthigi, Akhil

AU - George, Arvin

AU - Su, Daniel

AU - Merino, Maria J.

AU - Linehan, W. Marston

AU - Boyle, Shawna L.

AU - Metwalli, Adam R.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.

AB - Magnetic Resonance Imaging (MRI) and fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) are recognized approaches for locating paragangliomas. Recently, gallium-68 DOTA-octreotate (DOTATATE) scans have shown promise detecting neuroendocrine tumors missed by FDG-PET and MRI. 13-year-old male with SDH-B mutation presented with symptoms of paraganglioma and elevated catecholamines. MRI did not demonstrate the T2 hyper intense signal typical of paraganglioma and pheochromocytoma; FDG-PET scan did not reveal increased foci of uptake. DOTATATE scan revealed a signal consistent only with residual adrenal tissue. Resection of the right adrenal bed revealed paraganglioma. Following surgery, no further symptoms were reported and biochemical tests normalized.

KW - Adrenalectomy

KW - Nephrectomy

KW - Paraganglioma

KW - Succinate dehydrogenase B mutation

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DO - 10.1016/j.eucr.2017.03.017

M3 - Article

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SN - 2214-4420

VL - 13

SP - 107

EP - 109

JO - Urology case reports

JF - Urology case reports

ER -

Multiple Recurrent Paraganglioma in a Pediatric Patient with Germline SDH-B Mutation

Abstract

Keywords

ASJC Scopus subject areas

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