Multimodality Imaging of Cerebral Crystal-Storing Histiocytosis: Distinguishing Imaging Characteristics and a Literature Review of a Very Rare Entity

Crystal-storing histiocytosis is a rare immunoglobulin storage disorder most frequently associated with lymphoproliferative diseases and characterized by intracytoplasmic accumulations of fibrillar and crystalloid inclusions. The inclusions have been described in a variety of anatomic sites but with only a few reported cases of CNS involvement. We presented 2 patients with cerebral crystal-storing histiocytosis and described the imaging characteristics that may distinguish brain parenchymal involvement by crystal-storing histiocytosis from other, more commonly encountered mass lesions.