Multimodal objective assessment of impulsivity in healthy and mood disorder participants

Bishal Lamichhane; Nidal Moukaddam; Ramiro Salas; Wayne Goodman; Ashutosh Sabharwal

doi:10.1038/s44277-025-00026-z

Multimodal objective assessment of impulsivity in healthy and mood disorder participants

Bishal Lamichhane, Nidal Moukaddam, Ramiro Salas, Wayne Goodman, Ashutosh Sabharwal

Research output: Contribution to journal › Article › peer-review

Abstract

Impulsivity represents an individual’s tendency to act on urges without sufficient forethought. Heightened impulsivity is a hallmark of many mental health disorders. Objective impulsivity assessments could improve risk evaluation, diagnosis, and behavioral outcome monitoring in impulsivity-related health disorders. Towards objective impulsivity assessment, in this work, we identify impulsivity correlates in objective measurements, investigate their complementarity, and contrast impulsivity mechanisms across health conditions. We analyzed behavioral tests, heart rate variability (HRV), and fMRI-based brain connectivity in 227 healthy participants and 34 participants with mood disorders. Impulsivity dimensions had complementary correlates in objective measurements, with fMRI providing the strongest correlates. Multimodal assessment provided high r-squared (adjusted) values in modeling impulsivity of the mood disorder participants (e.g., r-squared of 0.73, p

Original language	English (US)
Journal	NPP—Digital Psychiatry and Neuroscience
Volume	3
Issue number	1
DOIs	https://doi.org/10.1038/s44277-025-00026-z
State	Published - Feb 14 2025

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AU - Salas, Ramiro

AU - Goodman, Wayne

AU - Sabharwal, Ashutosh

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Multimodal objective assessment of impulsivity in healthy and mood disorder participants

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