Multihydroxylated [Gd@C82(OH)22]n nanoparticles: Antineoplastic activity of high efficiency and low toxicity

Chunying Chen; Gengmei Xing; Jiangxue Wang; Yuliang Zhao; Bai Li; Jun Tang; Guang Jia; Tiancheng Wang; Jin Sun; Li Xing; Hui Yuan; Yuxi Gao; Huan Meng; Zhen Chen; Feng Zhao; Zhifang Chai; Xiaohong Fang

doi:10.1021/nl051624b

Multihydroxylated [Gd@C₈₂(OH)₂₂]_n nanoparticles: Antineoplastic activity of high efficiency and low toxicity

Chunying Chen, Gengmei Xing, Jiangxue Wang, Yuliang Zhao, Bai Li, Jun Tang, Guang Jia, Tiancheng Wang, Jin Sun, Li Xing, Hui Yuan, Yuxi Gao, Huan Meng, Zhen Chen, Feng Zhao, Zhifang Chai, Xiaohong Fang

Houston Methodist

Research output: Contribution to journal › Article › peer-review

316 Scopus citations

Abstract

[Gd@C₈₂(OH)₂₂]_n particles (22 nm in a saline solution) of a dose level as low as 10 7 mol/kg exhibit a very high antineoplastic efficiency (∼60%) in mice. A dose increment of 1 × 10^-7 mol/kg increases the tumor inhibition rate 26%. [Gd@C ₈₂(OH)₂₂]_n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.

Original language	English (US)
Pages (from-to)	2050-2057
Number of pages	8
Journal	Nano Letters
Volume	5
Issue number	10
DOIs	https://doi.org/10.1021/nl051624b
State	Published - Oct 2005

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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title = "Multihydroxylated [Gd@C82(OH)22]n nanoparticles: Antineoplastic activity of high efficiency and low toxicity",

abstract = "[Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10 7 mol/kg exhibit a very high antineoplastic efficiency (∼60%) in mice. A dose increment of 1 × 10-7 mol/kg increases the tumor inhibition rate 26%. [Gd@C 82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.",

author = "Chunying Chen and Gengmei Xing and Jiangxue Wang and Yuliang Zhao and Bai Li and Jun Tang and Guang Jia and Tiancheng Wang and Jin Sun and Li Xing and Hui Yuan and Yuxi Gao and Huan Meng and Zhen Chen and Feng Zhao and Zhifang Chai and Xiaohong Fang",

year = "2005",

month = oct,

doi = "10.1021/nl051624b",

language = "English (US)",

volume = "5",

pages = "2050--2057",

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T1 - Multihydroxylated [Gd@C82(OH)22]n nanoparticles

T2 - Antineoplastic activity of high efficiency and low toxicity

AU - Chen, Chunying

AU - Xing, Gengmei

AU - Wang, Jiangxue

AU - Zhao, Yuliang

AU - Li, Bai

AU - Tang, Jun

AU - Jia, Guang

AU - Wang, Tiancheng

AU - Sun, Jin

AU - Xing, Li

AU - Yuan, Hui

AU - Gao, Yuxi

AU - Meng, Huan

AU - Chen, Zhen

AU - Zhao, Feng

AU - Chai, Zhifang

AU - Fang, Xiaohong

PY - 2005/10

Y1 - 2005/10

N2 - [Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10 7 mol/kg exhibit a very high antineoplastic efficiency (∼60%) in mice. A dose increment of 1 × 10-7 mol/kg increases the tumor inhibition rate 26%. [Gd@C 82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.

AB - [Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10 7 mol/kg exhibit a very high antineoplastic efficiency (∼60%) in mice. A dose increment of 1 × 10-7 mol/kg increases the tumor inhibition rate 26%. [Gd@C 82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.

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DO - 10.1021/nl051624b

M3 - Article

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AN - SCOPUS:27544502160

SN - 1530-6984

VL - 5

SP - 2050

EP - 2057

JO - Nano Letters

JF - Nano Letters

IS - 10

ER -

Multihydroxylated [Gd@C₈₂(OH)₂₂]_n nanoparticles: Antineoplastic activity of high efficiency and low toxicity

Abstract

ASJC Scopus subject areas

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