Multihydroxylated [Gd@C82(OH)22]n nanoparticles: Antineoplastic activity of high efficiency and low toxicity

Chunying Chen, Gengmei Xing, Jiangxue Wang, Yuliang Zhao, Bai Li, Jun Tang, Guang Jia, Tiancheng Wang, Jin Sun, Li Xing, Hui Yuan, Yuxi Gao, Huan Meng, Zhen Chen, Feng Zhao, Zhifang Chai, Xiaohong Fang

Research output: Contribution to journalArticle

266 Scopus citations

Abstract

[Gd@C82(OH)22]n particles (22 nm in a saline solution) of a dose level as low as 10 7 mol/kg exhibit a very high antineoplastic efficiency (∼60%) in mice. A dose increment of 1 × 10-7 mol/kg increases the tumor inhibition rate 26%. [Gd@C 82(OH)22]n particles have a strong capacity to improve immunity and interfere with tumor invasion in normal muscle cells, nearly without toxicity in vivo and in vitro. Unlike conventional antineoplastic chemicals, the high antitumor efficiency of nanoparticles is not due to toxic effects to cells because they do not kill the tumor cells directly and only about 0.05% of the used dose is found in the tumor tissues. Results suggest that fullerene derivatives with proper surface modifications and sizes may help realize the dream of tumor chemotherapeutics of high-efficacy and low-toxicity.

Original languageEnglish (US)
Pages (from-to)2050-2057
Number of pages8
JournalNano Letters
Volume5
Issue number10
DOIs
StatePublished - Oct 2005

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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