Multifunctional Rbx WO3 nanorods for simultaneous combined chemo-photothermal therapy and photoacoustic/CT imaging

Gan Tian, Xiao Zhang, Xiaopeng Zheng, Wenyan Yin, Longfei Ruan, Xiaodong Liu, Liangjun Zhou, Liang Yan, Shoujian Li, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

Light-triggered drug delivery based on near-infrared (NIR)-mediated photothermal nanocarriers has received tremendous attention for the construction of cooperative therapeutic systems in nanomedicine. Herein, a new paradigm of light-responsive drug carrier that doubles as a photothermal agent is reported based on the NIR lightabsorber, Rbx WO3 (rubidium tungsten bronze, Rb-TB) nanorods. With doxorubicin (DOX) payload, the DOX-loaded Rb-TB composite (Rb-TB-DOX) simultaneously provides a burst-like drug release and intense heating effect upon 808-nm NIR light exposure. MTT assays show the photothermally enhanced antitumor activity of Rb-TB-DOX to the MCF-7 cancer cells. Most remarkably, Rb-TB-DOX combined with NIR irradiation also shows dramatically enhanced chemotherapeutic effect to DOX-resistant MCF-7 cells compared with free DOX, demonstrating the enhanced effi cacy of combinational chemo-photothermal therapy for potentially overcoming drug resistance in cancer chemotherapy. Furthermore, in vivo study of combined chemo-photothermal therapy is also conducted and realized on pancreatic (Pance-1) tumor-bearing nude mice. Apart from its promise for cancer therapy, the as-prepared Rb-TB can also be employed as a new dual-modal contrast agent for photoacoustic tomography and (PAT) X-ray computed tomography (CT) imaging because of its high NIR optical absorption capability and strong X-ray attenuation ability, respectively. The results presented in the current study suggest promise of the multifunctional Rbx WO3 nanorods for applications in cancer theranostics.

Original languageEnglish (US)
Pages (from-to)4160-4170
Number of pages11
JournalSmall
Volume10
Issue number20
DOIs
StatePublished - Oct 29 2014

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology

Fingerprint Dive into the research topics of 'Multifunctional Rb<sub>x</sub> WO<sub>3</sub> nanorods for simultaneous combined chemo-photothermal therapy and photoacoustic/CT imaging'. Together they form a unique fingerprint.

Cite this