Multifocal osteosarcoma: An unusual presentation

Sriya Gunawardena, Murali Chintagumpala, Lynn Trautwein, Eileen Brewer, Mary V. Gresik, M. John Hicks, Wilbur R. Harrison, Ammar Morad, Linda D. Cooley

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Purpose: Report the unusual presentation, clinical course, and cytogenetic abnormalities in a child with multifocal osteosarcoma. Patients and Methods: A 10-year-old boy had multifocal osteosarcoma involving the entire skeleton, pleura, bone marrow, and lungs. He had marked anemia, thrombocytopenia, and severe hypocalcemia at diagnosis. Results: Despite aggressive chemotherapy, he died from progressive disease 1 month after diagnosis. Cytogenetic analysis of tumor cells within the pleural fluid showed multiple chromosomal abnormalities with amplification of the c-myc oncogene. Conclusion: Multifocal osteosarcoma should be considered in the differential diagnosis of a child with pancytopenia and multiple bone lesions. Amplification of the c-myc oncogene may have had a significant role in the pathogenesis, etiology, and rapid progression of this patient's multifocal disease. Additional studies will be needed to determine the biologic significance of c-myc amplification in multifocal osteosarcoma.

Original languageEnglish (US)
Pages (from-to)58-62
Number of pages5
JournalJournal of pediatric hematology/oncology
Issue number1
StatePublished - 1999


  • C-myc amplification
  • Hypocalcemia
  • Multifocal osteosarcoma
  • Thrombocytopenia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Hematology


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