TY - JOUR
T1 - Multidisciplinary cooperation in a simultaneous combined liver and kidney transplantation patient of primary hyperoxaluria 1
AU - Ren, Qingqi
AU - Ju, Weiqiang
AU - Wang, Dongping
AU - Guo, Zhiyong
AU - Chen, Maogen
AU - He, Xiaoshun
N1 - Publisher Copyright:
© 2017, Nepal Medical Association. All rights reserved.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2017
Y1 - 2017
N2 - Primary hyperoxaluria type 1 is an autosomal recessive hereditary glyoxylate metabolism disorder characterized by excessive production of oxalate, caused by the deficiency of liver specific peroxisomal enzyme: alanineglyoxylate aminotransferase. For patients with end-stage renal disease, combined liver and kidney transplantation was needed. This report describes one patient, with a diagnosis of end-stage renal disease and primary hyperoxaluria 1 confirmed by PCR and direct sequencing with genomic DNA, received the simultaneous combined liver and kidney transplantation after seven months’ waiting. However, there were several complications observed post surgery, such as protracted bleeding, common bile duct anastomotic stenosis, biliary calculi and recurrence of urolithiasis. All these were well solved by relevant department, and finally a satisfactory outcome was achieved. Multidisciplinary cooperation plays an important role on the PH1 patient management, especially when multiple complications are encountered.
AB - Primary hyperoxaluria type 1 is an autosomal recessive hereditary glyoxylate metabolism disorder characterized by excessive production of oxalate, caused by the deficiency of liver specific peroxisomal enzyme: alanineglyoxylate aminotransferase. For patients with end-stage renal disease, combined liver and kidney transplantation was needed. This report describes one patient, with a diagnosis of end-stage renal disease and primary hyperoxaluria 1 confirmed by PCR and direct sequencing with genomic DNA, received the simultaneous combined liver and kidney transplantation after seven months’ waiting. However, there were several complications observed post surgery, such as protracted bleeding, common bile duct anastomotic stenosis, biliary calculi and recurrence of urolithiasis. All these were well solved by relevant department, and finally a satisfactory outcome was achieved. Multidisciplinary cooperation plays an important role on the PH1 patient management, especially when multiple complications are encountered.
KW - End-stage renal disease
KW - Kidney transplantation
KW - Liver transplantation
KW - Primary hyperoxaluria type 1
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U2 - 10.31729/jnma.2671
DO - 10.31729/jnma.2671
M3 - Article
C2 - 28598458
AN - SCOPUS:85018683593
SN - 0028-2715
VL - 56
SP - 175
EP - 178
JO - Journal of the Nepal Medical Association
JF - Journal of the Nepal Medical Association
IS - 205
ER -