Multidisciplinary cooperation in a simultaneous combined liver and kidney transplantation patient of primary hyperoxaluria 1

Qingqi Ren, Weiqiang Ju, Dongping Wang, Zhiyong Guo, Maogen Chen, Xiaoshun He

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Primary hyperoxaluria type 1 is an autosomal recessive hereditary glyoxylate metabolism disorder characterized by excessive production of oxalate, caused by the deficiency of liver specific peroxisomal enzyme: alanineglyoxylate aminotransferase. For patients with end-stage renal disease, combined liver and kidney transplantation was needed. This report describes one patient, with a diagnosis of end-stage renal disease and primary hyperoxaluria 1 confirmed by PCR and direct sequencing with genomic DNA, received the simultaneous combined liver and kidney transplantation after seven months’ waiting. However, there were several complications observed post surgery, such as protracted bleeding, common bile duct anastomotic stenosis, biliary calculi and recurrence of urolithiasis. All these were well solved by relevant department, and finally a satisfactory outcome was achieved. Multidisciplinary cooperation plays an important role on the PH1 patient management, especially when multiple complications are encountered.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalJournal of the Nepal Medical Association
Volume56
Issue number205
DOIs
StatePublished - 2017

Keywords

  • End-stage renal disease
  • Kidney transplantation
  • Liver transplantation
  • Primary hyperoxaluria type 1

ASJC Scopus subject areas

  • General Medicine

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