Multicomponent Lyme vaccine: Three is not a crowd

Eric L. Brown, Jung Hwa Kim, Emily S. Reisenbichler, Magnus Höök

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Lyme disease is caused by the spirochete Borrelia burgdorferi and it is the most common vector-borne disease in the United States. Disseminated spirochetes can persist in various tissues and can result in a variety of different disease manifestations. Vaccination trials testing various lipoprotein candidates have yielded mixed results despite the generation of robust antibody titers. Data presented in this report demonstrate that a combination vaccine composed of DbpA, BBK32 and OspC is more effective than single or double component formulations and that the ratio of each component dramatically impacts vaccine efficacy when tested in protection experiments against Borrelia following needle inoculation.

Original languageEnglish (US)
Pages (from-to)3687-3696
Number of pages10
JournalVaccine
Volume23
Issue number28
DOIs
StatePublished - May 25 2005

Keywords

  • Borrelia burgdorferi
  • Lyme disease
  • Prozone
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

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