Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: A case report, investigation of mtor activation and review of the literature

Qi Shen, Wei Feng, Michael S. Long, Xiuzhen Duan, Siraya Jaijakul, Cesar A. Arias, Robert E. Brown, Bihong Zhao

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Epstein-Barr virus (EBV) - associated smooth muscle tumors (EBV-SMT) are a rare, recently recognized distinct group of mesenchymal tumors that develop exclusively in patients with immunosuppression. It is believed that tumorigenesis is, at least in part, through the activation of the Akt/mammalian target of rapamycin (mTOR) signal pathway. We describe the clinicopathologic and immunohistochemical features of a multifocal hepatic EBV-SMT in a 34-year-old acquired immunodeficiency syndrome (AIDS) patient and investigate the activation status of the mTOR signal pathway in this tumor. In addition, we provide a review of the literature on the clinicopathologic findings of hepatic EBV-SMT in adult AIDS patients, and discuss their biologies and possible therapeutic strategies.

Original languageEnglish (US)
Pages (from-to)421-429
Number of pages9
JournalInternational journal of clinical and experimental pathology
Volume4
Issue number4
StatePublished - Nov 2 2011

Keywords

  • Acquired immunodeficiency syndrome
  • Adult
  • Epstein-Barr virus
  • HIV infection
  • Liver
  • Smooth muscle tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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